GHRP-2 10mg/vial Highly Effective Stimulation Of The Pituitary Gland To Release Growth Hormone

GHRP-2 10mg/bottle core introduction

Growth hormone releasing peptide-2 | Growth hormone secretagogue 10mg/bottle

Generic name : Growth hormone releasing peptide-2

English name : GHRP-2 (Growth Hormone Releasing Peptide-2)

Sequence : D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH2

Molecular weight : Approximately 817.0 Da

Purity : ≥98.0% (HPLC)

Content : 10mg/bottle

Appearance : White lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.

Usage and Storage Guide

GHRP-2 (Growth Hormone Releasing Peptide-2):

GHRP-2 is a synthetic growth hormone secretagogue that effectively stimulates the pituitary gland to release endogenous growth hormone by selectively activating growth hormone secretagogue receptors. Compared to GHRP-6, GHRP-2 has an optimized structure, exhibiting stronger receptor affinity and a longer duration of action, demonstrating a more sustained growth hormone release effect in experiments. In exercise physiology studies, GHRP-2 is frequently used to evaluate the regulatory role of endogenous growth hormone on muscle anabolism.

Due to its potent growth hormone release capacity, GHRP-2 is of significant value in studying the effects of growth hormone on muscle protein synthesis, lipolysis, and exercise recovery. GHRP-2 can serve as a standardized experimental tool to help researchers explore the potential role of growth hormone in improving athletic performance when assessing the mechanisms by which growth hormone contributes to strength training adaptation, muscle hypertrophy, and body composition improvement.

GHRP-2 Applications:

As a highly efficient growth hormone secretagogue, it is mainly used to study its effects on pulsatile growth hormone secretion and to evaluate its regulatory role in muscle protein synthesis rate, lipid oxidation efficiency, and post-exercise recovery in experimental models. It is an important tool in exercise metabolism research and the exploration of muscle adaptation mechanisms.

It is applied to exercise physiology experiments, anti-catabolism studies, analysis of muscle hypertrophy mechanisms, and studies on body composition improvement, providing a reliable research basis for evaluating the physiological effects of growth hormone in the process of exercise adaptation under strictly controlled conditions.

Usage and Storage Methods

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : sterile water for injection

Carrier solution : diluted with sterile physiological saline for in vivo studies.

Important note : Avoid using strong acid or strong alkali solutions. Stability is optimal under neutral conditions.

Standard preparation procedure :

Solvent preparation :

Use sterile water for injection that has been aseptically filtered through a 0.22 μm filter membrane.

The solvent temperature was restored to room temperature (20-25℃).

Reconstitution procedure :

Add 1.0 mL of sterile water for injection to a 10 mg vial.

Pour slowly along the bottle wall to avoid direct impact on the powder.

Gently rotate the vial for 3-5 minutes until completely dissolved and the solution becomes clear.

Final concentration: 10 mg/mL.

Dispensing and dilution :

Immediately dispense into single-use doses of 20-50 μL using low-adsorption cryovials.

Dilute with sterile saline to the required working concentration.

Clearly label: name, concentration, preparation date, batch number, and storage conditions.

Working concentration/dosage reference :

In vitro experiments : The commonly used concentration range is 0.1 nM to 1 μM, and preliminary experiments need to be conducted to optimize the concentration based on the specific experimental system.

Animal experiments :

Subcutaneous injection : The usual dosage range is 1 to 10 μg/kg.

It is strongly recommended that the precise dosage be determined based on the specific animal model, route of administration, research objectives, and published literature.

Example of preparation calculation : If a 100 μg/mL working solution is required, take 0.01 mL of stock solution and add it to 0.99 mL of physiological saline.

Key points to note :

Strict aseptic technique : Operate in a clean bench and use sterile consumables, especially when administering drugs in vivo.

Avoid light : It is sensitive to light, so it is recommended to operate it in a dark environment.

Prepare and use immediately : After reconstitution, it should be used within 24 hours. After dispensing, store under the specified conditions.

Avoid adsorption : Using silanized low-adsorption tubes can reduce adsorption loss on the tube wall.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Freeze at -20℃, shelf life 24 months.

Optimal storage : -80°C deep freeze, shelf life 36 months.

Strictly protected from light : Must be stored in the original light-proof aluminum foil bag.

Moisture protection : Keep dry; contains desiccant.

Reconstituted solution :

Use immediately : For best activity, use immediately after reconstitution.

Short-term storage : Refrigerate at 2-8℃ away from light, for no more than 24 hours.

Repackage and freeze : Store at -20℃ or -80℃ away from light for no more than 72 hours.

Repeated freeze-thaw cycles are strictly prohibited : a maximum of one freeze-thaw cycle.

Transportation conditions :

Freeze-dried powder : transported by dry ice (-78℃).

Short-term shipping : 2-8℃ ice pack shipping, ensuring delivery within 48 hours.

3. Stability and Processing Standards :

Chemical and physical stability :

It is relatively stable in neutral pH aqueous solutions.

Avoid contact with strong acids, strong alkalis, and oxidizing agents.

It is sensitive to high temperatures, so low-temperature storage is recommended.

Maintenance of bioactivity :

Proper storage conditions and appropriate preparation methods are key to maintaining activity.

To avoid repeated freeze-thaw cycles, it is recommended to store the contents in smaller portions.

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