GHRP-2 5mg/vial Highly Effective Stimulation Of The Pituitary Gland To Release Growth Hormone

GHRP-2 5mg/bottle core introduction

Growth hormone releasing peptide-2 | Growth hormone secretagogue 5mg/bottle

Generic name : Growth hormone releasing peptide-2

English name : GHRP-2 (Growth Hormone Releasing Peptide-2)

Sequence : D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH2

Molecular weight : Approximately 817.0 Da

Purity : ≥98.0% (HPLC)

Content : 5mg/bottle

Appearance : White lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.

Usage and Storage Guide

GHRP-2 (Growth Hormone Releasing Peptide-2):

GHRP-2 is a synthetically produced, highly selective growth hormone-secreting hormone (GH-CSH) that efficiently stimulates the pituitary gland to release endogenous growth hormone by specifically activating the GH-CSH receptor (GHS-R). Compared to GHRP-6, GHRP-2 has higher receptor affinity, stronger GH-CSH-releasing potency, and a longer biological half-life, thus allowing for more sustained and stable pulsatile GH-secreting in experimental models. In exercise physiology research, GHRP-2 is a standardized tool for studying the anabolic effects of growth hormone and assessing its influence on muscle protein synthesis, lipid oxidation, and post-training recovery.

In the field of sports science research, GHRP-2 is widely used to evaluate the potential mechanisms by which growth hormone promotes lean body mass increase, optimizes body composition, improves athletic performance, and accelerates post-training recovery because it can effectively increase endogenous growth hormone levels. It provides a controllable experimental model for exploring the physiological roles of growth hormone in strength training, endurance exercise, and anti-catabolic processes.

GHRP-2 Applications:

As a potent and highly selective growth hormone secretagogue, GHRP-2 is primarily used to study the secretion kinetics of endogenous growth hormone and its regulatory effects on muscle protein synthesis, lipolysis, and post-exercise tissue repair. It is a key experimental tool for investigating the role of growth hormone in promoting muscle hypertrophy, enhancing strength, improving body composition (increasing muscle mass and reducing fat), and accelerating recovery.

It is applied to scientific research related to muscle anabolic metabolism, anti-catabolism experiments, analysis of athletic performance improvement mechanisms, post-training recovery assessment, and body composition improvement, providing standardized experimental evidence for accurately quantifying the physiological effects of growth hormone in optimizing exercise adaptation.

Usage and Storage Methods

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : sterile water for injection

Carrier solution : diluted with sterile physiological saline for in vivo studies.

Important note : Avoid using strong acid or strong alkali solutions. Optimal stability is achieved under neutral to slightly acidic conditions.

Standard preparation procedure :

Solvent preparation :

Use sterile water for injection that has been aseptically filtered through a 0.22 μm filter membrane.

The solvent temperature was restored to room temperature (20-25℃).

Reconstitution procedure :

Add 1.0-2.0 mL of sterile water for injection to a 5 mg vial.

Pour slowly along the bottle wall to avoid direct impact on the powder.

Gently rotate the vial for 3-5 minutes until completely dissolved and the solution becomes clear.

Common final concentrations: 5 mg/mL or 2.5 mg/mL.

Dispensing and dilution :

Immediately dispense into single-use doses of 20-50 μL using low-adsorption cryovials.

Dilute with sterile saline to the required working concentration.

Clearly label: name, concentration, preparation date, batch number, and storage conditions.

Working concentration/dosage reference :

In vitro cell experiments : The commonly used concentration range is 0.1 nM to 1 μM, and preliminary experiments need to be performed to optimize the concentration based on the specific cell type and experimental purpose.

Animal experiments :

Subcutaneous injection : The usual dosage range is 1 to 10 μg/kg, once or twice daily.

Intramuscular injection : Can be used for local muscle studies; dosage needs to be optimized based on the experimental model.

It is strongly recommended that the precise dosage be determined based on preliminary experiments, specific routes of administration, animal species, and published literature.

Example of preparation calculation : If a 100 μg/mL working solution is required, take 0.02 mL of stock solution (5 mg/mL) and add it to 0.98 mL of physiological saline.

Key points to note :

Dissolve gently : Avoid swirling or violent shaking; simply rotate gently to dissolve.

Strict aseptic technique : Operate in a clean bench and use sterile consumables, especially when administering drugs in vivo.

Completely avoid light : It is sensitive to light, and all steps must be carried out under light-protected conditions.

Prepare and use immediately : The stability is limited after reconstitution, so it is recommended to use it as soon as possible. After repackaging, store it under the specified conditions.

To avoid adsorption : dilution with a solution containing 0.1% bovine serum albumin or silanized low-adsorption tubes can reduce adsorption on the tube walls.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Freeze at -20℃, shelf life 24 months.

Optimal storage : -80°C deep freeze, shelf life 36 months.

Strictly protected from light : Must be stored in the original light-proof aluminum foil bag.

Moisture protection : Keep dry; contains desiccant.

Reconstituted solution :

Use immediately : For best activity, use immediately after reconstitution.

Short-term storage : Refrigerate at 2-8℃ away from light, for no more than 24 hours.

Repackage and freeze : Store at -20℃ or -80℃ away from light for no more than 1 week.

Repeated freeze-thaw cycles are strictly prohibited : a maximum of one freeze-thaw cycle.

Transportation conditions :

Freeze-dried powder : transported by dry ice (-78℃).

Short-term shipping : 2-8℃ ice pack shipping, ensuring delivery within 48 hours.

Packaging : Light-proof aluminum foil bag + vacuum seal + foam insulated box.

3. Stability and Processing Standards :

Chemical and physical stability :

It is relatively stable in weakly acidic aqueous solutions.

Avoid contact with strong acids, strong alkalis, and oxidizing agents.

It is sensitive to high temperatures and mechanical stress.

Maintenance of bioactivity :

Proper aliquoting and storage at -80°C are key to maintaining long-term activity.

Thaw and dispense the liquid slowly on ice or under refrigeration before use.

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