Liraglutide 2mg/vial Effectively Controls Blood Sugar, Reduces Weight, And Protects The Cardiovascular System

Liraglutide 2mg/vial core introduction

Long-acting GLP-1 receptor agonist | Fatty acid modified glucose-lowering and weight-loss peptides 2mg/bottle

Generic name : liraglutide

Sequence : Based on the structure of human GLP-1 (7-37), modified by amino acid substitution and fatty acid side chain modification.

Molecular weight : Approximately 3751.2 Da

Purity : ≥99.0% (HPLC)

Appearance : White to off-white lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.

Usage and Storage Guide

Liraglutide:

Liraglutide is an engineered, long-acting glucagon-like peptide-1 (GLP-1) analogue that reversibly binds to albumin via its fatty acid side chain, significantly prolonging its half-life and enabling stable control of blood glucose and weight with once-daily dosing. Compared to natural GLP-1, it is more stable and has a longer duration of action in vivo. Its potent GLP-1 receptor agonist action not only promotes insulin secretion and inhibits glucagon in a glucose-dependent manner, but also delays gastric emptying and acts on the central nervous system to suppress appetite. Its proven efficacy makes it an important research tool in studying the pathophysiological mechanisms and treatment strategies of type 2 diabetes, obesity, and their complications.

Liraglutide is frequently chosen by researchers of metabolic diseases due to its widely validated blood glucose-lowering and weight-loss effects, as well as the ease with which its once-daily dosing regimen facilitates the observation of physiological rhythm changes in animal experiments. It works by precisely activating the GLP-1 receptor, avoiding the complex side effects associated with sex hormones. Its core role in regulating glycemic homeostasis, energy metabolism, and eating behavior makes it a standardized tool with a well-defined mechanism and reliable results in preclinical models of metabolic syndrome, insulin resistance, and obesity-related diseases.

Liraglutide Applications:

It activates the GLP-1 receptor, promoting insulin secretion and inhibiting glucagon release in a glucose-dependent manner, effectively delaying gastric emptying and producing a central feeling of satiety. Liraglutide is a long-acting hypoglycemic and weight management peptide developed based on fatty acid side-chain modification technology, and is an important reference molecule in metabolic research.

Liraglutide is widely used in the study of the pathological mechanisms and pharmacodynamics of type 2 diabetes, obesity, and related metabolic diseases. Its well-defined pharmacokinetic and pharmacodynamic characteristics provide a high-quality experimental model for evaluating novel GLP-1 drugs, exploring combination therapy regimens, and researching long-term metabolic intervention strategies. It also plays a crucial role in basic research areas such as food intake regulation, energy expenditure, and lipid metabolism.

Usage and storage methods

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : The included sterile diluent or a dedicated buffer solution with pH 8.0-8.5.

Important Note : Do not use ordinary saline, sterile water for injection, or other unverified solvents . Incorrect solvents may cause precipitation and inactivation.

For experimental dilution : After dissolving in the above-mentioned special solvent, it can be diluted a second time with physiological saline containing 0.1% bovine serum albumin (BSA) .

Standard preparation procedure :

Solvent preparation :

Use a dedicated solvent that has been sterilely filtered through a 0.22μm filter membrane.

The solvent temperature was restored to room temperature (20-25℃).

Reconstitution procedure :

Add 1.0 mL of the special solvent to a 2 mg vial.

Pour slowly along the bottle wall to avoid direct impact on the freeze-dried cake.

Gently rotate the vial horizontally in the palm of your hand for at least 2-3 minutes until a clear or slightly opalescent solution forms. Vigorous shaking, agitation, or vortexing is strictly prohibited .

Final concentration: 2 mg/mL (approximately 0.53 mM).

Dispensing and dilution :

If not used immediately, it should be dispensed into a single-experiment quantity using low-adsorption cryopreservation tubes as soon as possible.

For lower concentrations, use physiological saline containing 0.1% BSA for gradient dilution and gently invert to mix.

Working concentration/dosage reference :

In vitro cell experiments : Commonly used concentration range is 0.1 nM to 100 nM

Animal in vivo studies : The usual dosage range is 0.1 to 0.6 mg/kg (once daily, subcutaneous injection).

Example of preparation calculation : If a 10 nM working solution is required, take 18.9 μL of stock solution and add it to 1 mL of culture medium.

Key points to note :

Solvent specificity : Specific solvents must be used , which is crucial to ensuring its solubility and long-lasting properties.

Dissolving technique : Dissolve only by gently rotating horizontally. Any vigorous handling may cause protein denaturation or aggregation.

Aseptic and light-protected procedures : Strict aseptic operation and complete protection from light throughout the process.

Observe the solution : The solution should be clear or slightly opalescent after reconstitution. If precipitation, fibers or discoloration occur, the solution should be discarded.

Ready-to-use : After reconstitution, it should be used within 1 hour , or stored briefly as specified.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Store frozen at -20℃, shelf life 24 months.

Optimal storage : Store frozen at -80℃, shelf life 36 months.

Strictly protected from light : Must be stored in the original light-proof aluminum foil bag.

Moisture protection : Keep dry; contains desiccant.

Reconstituted solution :

Use immediately : For best activity, use immediately after reconstitution.

Short-term storage : Store at 2-8℃ away from light for no more than 24 hours.

Freezing is strictly prohibited : Solutions that have been reconstituted must not be frozen again .

Transportation conditions :

Freeze-dried powder : transported by dry ice (-78℃).

Packaging : Light-proof aluminum foil bag + vacuum seal + foam insulated box.

3. Stability and Processing Standards :

Physicochemical stability :

It is most stable under the pH conditions of a dedicated solvent.

It is sensitive to changes in pH and ionic strength of non-specific solvents and is prone to aggregation.

Sensitive to mechanical stress (such as violent vibration).

Key points for preserving active ingredients :

Strict adherence to dissolution and dilution procedures is fundamental to maintaining its biological activity and long-lasting pharmacokinetic properties.

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