Cortagen 20mg/vial Promotes Skin And Tissue Repair And Regeneration

Cortagen 20mg/bottle core introduction

Pharmaceutical-grade peptide formulations | Adrenocortical regulatory peptides made in China 20mg/vial

Specifications : 20mg/bottle, 5 bottles/box

Purity : ≥99% (HPLC detection)

Appearance : White lyophilized powder

Storage : Store frozen at -20℃ away from light; after thawing, refrigerate at 2-8℃.

Core advantages and functions

Cortagen is a bioactive peptide that targets adrenal cortex function . By precisely regulating the function of the hypothalamus-pituitary-adrenal axis and the balance of corticosteroid metabolism , it has important value in the fields of endocrine regulation, stress response research and treatment of metabolic diseases . It is a key tool for neuroendocrine research and adrenal function research .

✅Adrenal regulatory mechanism :

HPA axis regulation : regulating adrenocorticotropic hormone release

Cortisol Synthesis : Key Enzyme Activities Affecting Corticosteroid Synthesis

Stress adaptation : Enhancing the body's ability to adapt to stress.

Metabolic balance : regulating glucose and lipid metabolism

Inflammation regulation : modulating the inflammatory response through the hypothalamic-pituitary-adrenal axis

✅Quality advantages of Chinese manufacturers :

Design Innovation : Optimized Sequence Design Based on Endogenous Neuropeptides

Synthesis technology : Fmoc solid-phase synthesis combined with fragment condensation technology

Purification process : Preparative HPLC + ion exchange chromatography, purity ≥ 99.5%

Activity validation : In vitro adrenal cell model + in vivo HPA axis function test

Aseptic production : Class C cleanroom, automated filling and freeze-drying system

Quality control system : complete quality study documents + stability study data

✅Product Features :

Targeted and precise : specifically acts on adrenocortical cells

High stability : Special modifications enhance in vivo stability.

Good safety profile : Preclinical studies have shown good safety.

Synergistic effect : Can be used in combination with traditional hormone drugs

Usage and Storage Guide

1. Reconstitution and preparation :

Solvent selection :

First choice: Sterile saline

In vitro study: serum-free DMEM/F12 medium

Special Study: PBS buffer containing 0.1% BSA

Standard configuration :

Pour 2 mL of solvent into the 20 mg vial and gently swirl to dissolve.

A stock solution of 10 mg/mL was obtained .

Gradually dilute to the working concentration using the appropriate solvent.

Dissolution control :

Dissolution conditions: Dissolve at room temperature in the dark for 5-8 minutes.

Solution properties: Clear and transparent, without suspended matter.

pH control: Final pH 6.8-7.4

Contraindications: Avoid vibration, heating, and ultrasonic treatment.

2. Storage conditions :

Unopened :

Freeze at -20℃: Can be stored for 24 months

-80℃ deep freeze: can be stored for 36 months

Avoid repeated freeze-thaw cycles (≤3 times).

Reconstituted :

Stock solution: Stable for 5 days when refrigerated at 4°C.

Working solution: It is recommended to prepare and use immediately , and keep at 4°C for no more than 24 hours.

Store in smaller containers: Can be stored at -20℃ for 1 month.

Transportation conditions :

Dry ice transport (below -78℃)

Professional frozen transport packaging

Equipped with temperature recording equipment

Stability parameters :

Temperature: >37℃ accelerates degradation

pH range: 6.8-7.4 is the most stable

Light: Sensitive to ultraviolet light, requires handling in the dark.

Humidity: Store in an airtight container, protected from moisture.

3. Research and application plan :

In vitro cell experiments :

Cell model :

Human adrenocortical cells (NCI-H295R)

Mouse adrenal cortical cells (Y1)

Primary adrenocortical cells

Pituitary cells (AtT-20)

Concentration gradient :

Low concentration: 0.1-1 nM

Medium concentration: 1-10 nM

High concentration: 10-100 nM

Processing time :

Short-term: 15 minutes - 6 hours (signal path)

Mid-term: 12-48 hours (hormone synthesis)

Long-term: 72-120 hours (functional testing)

Evaluation indicators :

Hormone secretion: Cortisol and ACTH detection

Enzyme activities: CYP11B1, CYP11B2

Signaling pathways: cAMP, Ca²⁺ signal

Gene expression: qPCR, Western blot

Animal in vivo studies :

Disease model :

Chronic stress models: restraint stress and social frustration

Model of adrenocortical insufficiency

Cushing's syndrome model

Metabolic syndrome model

Route of administration :

Intraperitoneal injection: 0.2-1.0 mg/kg , once daily.

Subcutaneous injection: 0.1-0.5 mg/kg , once daily.

Intravenous injection: 0.05-0.2 mg/kg , once every other day.

Intraventricular injection: 2-10 μg/animal , for central nervous system research.

Dosage regimen :

Acute effects: Single dose, monitor for 0-24 hours.

Subacute: Once daily for 7-14 days

Chronic: Once daily for 4-8 weeks

Monitoring indicators :

Blood hormones: Cortisol, ACTH, CRH

Behavioral science: forced swimming, elevated cross maze

Metabolic indicators: blood glucose, blood lipids, weight

Histology: Adrenal gland morphology, pituitary gland morphology

Preclinical studies :

Pharmacokinetic studies

Safety assessment

Dosage exploration

Mechanism of action study

4. Experimental design optimization :

Dosage exploration :

Low dose: 0.1 mg/kg

Medium dose: 0.5 mg/kg

High dose: 1.0 mg/kg

Control group setup :

Blank control: physiological saline

Model comparison: Stress model + solvent

Positive control: Dexamethasone (0.5 mg/kg)

Time point design :

Pre-drug administration: baseline value determination

After administration: 0.5, 1, 2, 4, 8, 24 hours

Long-term observation: 1, 2, 4, 8 weeks

Sample collection :

Blood: Collected at different time points, plasma separated

Organs: Adrenal glands, pituitary gland, hypothalamus

Cerebrospinal fluid: collected by ventricular puncture

Detection method :

Hormone testing: ELISA, RIA

Behavioral testing

Histopathology

Molecular biological detection

Why choose Cortagen, made in China?

Technical advantages :

Autonomous design capability of neuroendocrine peptides

Advanced peptide modification and delivery technologies

A comprehensive pharmacodynamic and pharmacological research platform

Quality Guarantee :

Strict raw material screening and process control

Advanced analytical and testing equipment

Complete stability study data

High consistency in quality between batches

Service Support :

Professional technical support team

Detailed experimental protocol guidance

Literature support and research consultation

Customized services

Cost -effectiveness :

Large-scale production reduces costs

Compared to imported products, they have a clear price advantage.

Flexible packaging options

Research and application directions

Neuroendocrine research :

HPA Axis Function Adjustment Mechanism

Molecular basis of stress adaptation

Biological rhythms and endocrine regulation

Neuro-endocrine-immune network

Metabolic diseases :

Endocrine mechanisms of metabolic syndrome

Obesity and Hormonal Imbalance

Regulation of glucose and lipid metabolism

Energy metabolism balance

Mental and neurological disorders :

Endocrine mechanisms of depression

Stress response to anxiety disorder

Post-traumatic stress disorder

Neurodegenerative diseases

Translational medicine :

Development of novel endocrine regulators

Treatment of stress-related diseases

Treatment strategies for metabolic diseases

Exploring Personalized Treatment Plans

Summarize

Cortagen represents China's technological strength in the field of neuroendocrine peptide research . Through innovative peptide design, rigorous production control, and systematic activity validation , it provides high-quality, highly active research tools for global neuroendocrine research . This product has significant application value in HPA axis function research and the treatment of endocrine diseases , contributing to the advancement of the field of neuroendocrinology.

Technical Support :

We provide comprehensive technical support, including:

Detailed technical documents and quality certificates

Experimental design and optimization

Literature search and research consulting

Peptide modification and labeling services

Technical training and experimental guidance

Need anything, please contact us

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