Description

Technical Parameters

FOXO4 10mg/bottle core introduction

Pharmaceutical-grade peptide formulation | Made in China FOXO4-DRI (senescent cell scavenging peptide)

Chemical name : Ac-Gly-Thr-Glu-Gly-Gln-Ser-Arg-Lys-Lys-Arg-Arg-Gln-Lys-Ala-Lys-Lys-Asn-Arg-Arg-Lys-Lys-NH₂

Sequence : Ac-GTEGQSRKKRRQAKKKNRRKK-NH₂

CAS Number : Pending Assignment (New Molecular Entity)

Specification : 10mg/bottle

Dosage form : Lyophilized powder for injection

Molecular weight : Approximately 2.6 kDa

Appearance : White freeze-dried lumpy powder

Purity : ≥98% (HPLC detection)

Storage conditions : Store at -20℃ away from light.

Core Function | Core Effects

FOXO4-DRI is a peptide that targets and clears senescent cells . Due to its unique FOXO4-p53 interaction inhibition mechanism , it is widely used in research on aging-related diseases, cell senescence clearance, and anti-aging therapy .

✅Targeted clearance mechanism :

Specific binding : Targets the FOXO4 protein, disrupting the FOXO4-p53 interaction.

Senescent cell clearance : selectively induces apoptosis in senescent cells without affecting normal cells.

Tissue regeneration : Clears senescent cells, promotes tissue regeneration and functional recovery.

✅Quality advantages of Chinese manufacturing :

Purity Guaranteed : Solid-phase synthesis process, purity ≥98%, single impurities ≤0.1%.

Sequence accuracy : 100% correct amino acid sequence

Activity confirmation : Cellular level senescent cell clearance activity EC50 < 1 μM

✅Global supply assurance :

Cold chain logistics : -20℃ cold chain transportation throughout the entire process to ensure product stability.

Multi-warehouse delivery : Regional warehouses are established in China, Europe, America, and the Asia-Pacific region, ensuring delivery within 7 days.

Customs clearance support : Professional document preparation ensures smooth customs clearance worldwide.

Production process and quality assurance

1. Advanced synthesis process :

Solid-phase synthesis : The Fmoc solid-phase synthesis strategy was adopted, with a condensation efficiency >99.5%.

Acetylation modification : N-terminal specific acetylation enhances stability.

Purification process : Preparative HPLC purification, gradient elution, collection of the main peak.

2. Strict quality control standards :

Chemical purity :

Main component content: 98.0%~102.0%

Related substances: Single impurity ≤0.1%, total impurities ≤0.5%

Acetic acid content: ≤10.0% (ion chromatography)

Biological activity :

Senescent cell clearance assay: potency not less than 90% of the standard.

Cytotoxicity test: cytotoxicity to normal cells is below the specified limit.

3. Stability data :

Long-term stability : Stored at -20℃ for 24 months, all indicators meet the requirements.

Accelerated testing : After being stored at 25°C for 6 months, the purity decreased by ≤2.0%.

Stability in use : After reconstitution, store at 2-8℃ for 7 days; purity ≥95%.

Scientific Research Applications and Clinical Prospects

1. Mechanism of action study :

Targeted binding : Specifically binds to the FOXO4 protein, disrupting the FOXO4-p53 complex.

Selective apoptosis : Induces apoptosis in senescent cells without affecting normal cells.

Tissue repair : Clears senescent cells, promotes stem cell proliferation and tissue regeneration.

2. Research and application areas :

Anti-aging research : Mechanisms and treatments of age-related functional decline

Treatment of diseases : Treatment of age-related diseases such as osteoarthritis and atherosclerosis.

Regenerative medicine : Research on the mechanisms of tissue regeneration and functional recovery

3. Preclinical data :

Senescent cell clearance : Animal experiments show a 50-80% reduction in senescent cells.

Functional improvement : Improvement of age-related functional decline indicators

Good safety profile : minimal impact on normal tissues, wide therapeutic window.

Global supply and service assurance

1. Production capacity :

Annual production capacity : Over 100 grams per year

Flexible manufacturing : Customized specifications and packaging requirements are acceptable.

Production capacity assurance : Multiple production lines ensure stable supply

2. Quality Certification :

System Certification : Certified by ISO 9001 Quality Management System

Compliance with standards : Meets the standards for pharmaceutical polypeptide raw materials.

Complete documentation : Provides a complete package of quality documentation.

3. Logistics support :

Cryogenic packaging : Dry ice is used for transportation, and the temperature is maintained at -70℃ for ≥72 hours.

Real-time monitoring : Equipped with a temperature recorder, temperature data can be traced throughout the entire process.

Emergency Plan : Rapid Response and Abnormal Situation Handling Mechanism

Why choose FOXO4-DRI made in China?

Mechanism Innovation : The first aging-clearing peptide targeting the interaction between FOXO4 and p53

High selectivity : Specifically removes senescent cells without affecting normal cells.

Exceptional purity : Over 98% high purity, with strict quality control.

Stable supply : A complete supply chain ensures timely and reliable delivery.

Summarize

FOXO4-DRI 10mg lyophilized powder for injection, made in China, represents a high-quality standard in targeted aging clearance research . Through advanced synthesis processes, rigorous quality control, and a stable supply system , it provides high-quality, highly active research tools for global anti-aging and regenerative medicine research . Choosing Made in China means choosing research-grade quality and reliable assurance .

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