Description

Technical Parameters

Alprostadil 20mcg/vial (5 vials) - Core Introduction *

Pharmaceutical grade prostaglandin E1 | Made in China, vasoactive drug 20mcg/vial 5 *

Generic name : Prostaglandin E1

CAS No .: 745-65-3

Chemical name : (1R,2R,3R)-3-hydroxy-2-[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxocyclopentaneheptanoic acid

Molecular formula : C20H34O5

Molecular weight : 354.48

Specifications : 20 micrograms/vial, 5 vials/box

Appearance : White freeze-dried lumps or powder

Storage : Store in the refrigerator at 2-8℃, away from light.

Core advantages and functions

Alprostadil is a synthetic analogue of natural prostaglandin E1 (PGE1) and an important standard substance for vasoactivity research . Through multiple mechanisms , including direct relaxation of vascular smooth muscle, inhibition of platelet aggregation, improvement of erythrocyte deformability, and protection of vascular endothelium , it has classic and important applications in vascular physiology, cardiovascular disease, erectile dysfunction, peripheral vascular disease, and neonatal patent ductus arteriosus . It is a core tool drug for vascular biology and microcirculation research .

✅Core Mechanism of Action :

Vasodilation : Activates adenylate cyclase, increases intracellular cAMP levels, and relaxes vascular smooth muscle.

Antiplatelet aggregation : Inhibits platelet activation and aggregation, preventing thrombosis.

Cell protection : Stabilizes cell membranes, reduces free radical production, and protects ischemic tissues.

Improved blood flow : Significantly improves microcirculation and increases tissue blood perfusion.

Immune regulation : Regulates the release of inflammatory factors and reduces inflammatory responses.

Erectile function : Vasodilation of the corpora cavernosa promotes penile erection.

✅Quality advantages of Chinese manufacturers :

Synthesis process : Asymmetric synthesis technology is used , with strict control over chiral centers, achieving an optical purity of ≥99.5%.

Formulation technology : The application of liposome drug delivery technology significantly improves drug stability and targeting.

Quality system : Fully compliant with Chinese Pharmacopoeia (ChP) and European Pharmacopoeia (EP) standards.

Purity control :

Main component content: 90.0%-110.0%

Related substances: Single impurities ≤ 0.5%, total impurities ≤ 1.5%

Isomer control: Strictly control the content of 8-isomer

Bioequivalence : In vitro dissolution and pharmacodynamic parameters are consistent with the original drug.

Stability studies : Complete long-term stability (24 months) and accelerated stability (6 months) tests.

✅Product Features :

Liposphere formulations : improve drug stability and reduce irritation.

Targeted delivery : selective accumulation in diseased vascular regions

Extended half-life : from 5-10 minutes for conventional formulations to 30-60 minutes.

Improved tolerance : Significantly reduces local reactions such as phlebitis.

Usage and Storage Guide

1. Reconstitution and preparation :

Special solvent :

The supplied dedicated solvent (usually sterile saline or a buffer solution containing a stabilizer) must be used .

Solvents containing benzyl alcohol or other preservatives are strictly prohibited.

Standard preparation procedure :

Inject 1 ml of special solvent along the bottle wall

Gently rotate until completely dissolved; do not shake vigorously.

A clear solution with a concentration of 20 mcg/ml was obtained.

Further dilution with physiological saline as needed for the experiment.

Key points to note :

Use within 2 hours after dissolving.

Avoid prolonged contact with plastic containers

Do not mix with other drugs in the same container

Do not use if the solution becomes cloudy, develops a precipitate, or changes color.

2. Storage conditions :

Unopened :

Refrigerate at 2-8℃ and store in the original packaging away from light.

Validity period: 24 months

Freezing is strictly prohibited.

Reconstituted :

After preparation, it should be stored at 2-8℃.

Must be used within 2 hours

Do not use in multiple sessions

Transportation conditions :

2-8℃ cold chain transportation

Avoid drastic temperature changes

Avoid freezing

Stability considerations :

It is sensitive to light and must be operated in complete darkness.

Sensitive to temperature, avoid high temperatures.

Stable in pH range of 6.0-8.0

Why choose Alprostadil, made in China?

Technical advantages :

Mastering the core lipid microsphere preparation technology

Stabilizer formula with independent intellectual property rights

Advanced asymmetric synthesis process

A comprehensive quality control system

Quality Guarantee :

Meets domestic and international pharmacopoeia standards

Strict impurity control

High batch consistency

Complete quality research data

Summarize

Alprostadil, a classic prostaglandin drug , holds irreplaceable value in vascular biology and preclinical research . Chinese manufacturers, through advanced manufacturing processes, rigorous quality control, and continuous innovation and improvement , provide researchers with high-quality, highly stable research tools . Its multiple pharmacological effects and reliable safety profile make it an important choice for research on vascular-related diseases.

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