Description

Technical Parameters

SS -31 (Elareotide) 10mg/bottle Core Introduction

Pharmaceutical -Grade Peptide Preparation | SS-31 (Mitochondrial-Targeted Antioxidant Peptide )

Amino acid sequence : D-Arg-Dmt-Lys-Phe-NH₂

Molecular weight : 639.76 Da

Specifications : 10mg/bottle (lyophilized powder)

Dosage form : Lyophilized powder for injection

Appearance : White freeze-dried powder

Core Effects

SS-31 is a first-in-class mitochondrial-targeted antioxidant peptide . Due to its unique mechanism of action and excellent cytoprotective properties , it is widely used in the treatment of ischemia-reperfusion injury, neurodegenerative diseases, and aging-related diseases .

✅ Precise targeting mechanism :

Targeting the inner mitochondrial membrane : specifically binds to cardiolipin and stabilizes mitochondrial structure

Reduce oxidative stress : inhibit ROS production and protect mitochondrial function

Improve energy metabolism : Enhance ATP synthesis and restore cellular energy supply

✅ Multiple tissue protection :

Heart protection : Reduce myocardial infarction area and improve cardiac function

Neuroprotection : Reduces neuronal apoptosis and improves cognitive function

Renal protection : Reduce the risk of acute kidney injury and protect renal function

✅ Anti-aging properties :

Delaying cellular senescence : Reducing the senescence-associated secretory phenotype (SASP)

Improve mitochondrial function : Enhance cellular energy metabolism efficiency

Protecting telomere length : slowing down the process of cell replicative aging

✅ Advantages :

High specificity : Precisely targeting mitochondria with minimal side effects

Multi- organ protection : Benefits to the heart, brain, kidneys, and other systems

Broad clinical prospects : Potential new options for treating multiple diseases

Usage Protocol

1. Reconstitution Method :

Dilution options :

Sterile water for injection or normal saline

It is recommended to use a special diluent with an appropriate pH value

Preparation steps :

Sterilize the rubber stopper surface

Inject 1-2 ml of diluent

Mix gently by swirling to avoid violent shaking

Wait until completely dissolved to clear liquid

2. Injection dosage regimen :

Commonly used doses studied :

Animal studies: 0.5-5 mg/kg/day

Clinical studies: 0.05-0.5 mg/kg/day

Starting dose :

It is recommended to start with a low dose and gradually increase

Initial dose: 0.05 mg/kg/day

Treatment cycle :

Acute injuries: Short-term treatment for 7-14 days

Chronic diseases: 4-12 weeks long-term treatment

3. Key points of injection technique :

Injection route :

Subcutaneous injection: abdomen, thigh, etc.

Intravenous injection: slow push or intravenous drip

Local injection: local administration to the target organ

Injection method :

Subcutaneous injection: insert the needle at a 45-degree angle, changing the site each time

Intravenous injection: dilute and infuse slowly (over 30 minutes)

4. Special Application Solutions :

Heart protection :

Administer the drug 30 minutes before ischemia-reperfusion

Dosage: 0.1-0.5 mg/kg

Neuroprotection :

Once daily for 4-8 weeks

Dosage: 0.05-0.2 mg/kg/day

Kidney protection :

Start giving the drug before surgery and continue for 3-7 days after surgery

Dosage: 0.1-0.3 mg/kg/day

5. Notes :

Storage conditions :

Unreconstituted: Store frozen at -20°C

After preparation: Store at 2-8°C and use within 24 hours

Contraindications :

Contraindicated in patients allergic to peptides

Safety for pregnant and lactating women has not been established

Why choose SS-31 ?

Pioneering mechanism : The only antioxidant peptide targeting the inner mitochondrial membrane

Multi-organ protection : Coordinated protection of multiple systems including heart, brain, and kidneys

High safety : Specific targeting, mild side effects

Quality Assurance :

cGMP standard production : strict quality control system

Purity test : HPLC purity ≥98%

Sterility test : Each vial passes sterility and pyrogen test

Professional Packaging :

Vial packaging : 10mg/vial, sealed with rubber stopper

Cold chain transportation : -20°C frozen storage and transportation

Anti-counterfeiting traceability : QR code traceability system

Conclusion

SS-31 is an innovative option for mitochondrial-targeted therapy , particularly suitable for the research and treatment of ischemia-reperfusion injury, neurodegenerative diseases, and aging-related diseases . The recommended dose is 0.05-0.5mg/kg/day .

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