Tesamorelin 2mg/vial Specific Reduction Of Abdominal Visceral Fat

Tesamorelin 2mg/vial core introduction

Growth hormone releasing factor analogue | Long-acting GRF agonist 2mg/vial

Generic name : Temorelin

English name : Tesamorelin

Sequence : Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu- Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Gly-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂

Molecular weight : Approximately 5135.8 Da

Purity : ≥98.0% (HPLC)

Content : 2mg/bottle

Appearance : White lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.

Usage and Storage Guide

Tesamorelin:

Temorelin is a synthetic growth hormone-releasing factor analogue. By modifying the N-terminus of the natural GRF (1-44), its binding affinity to the growth hormone-releasing hormone receptor and its resistance to enzymatic degradation are significantly enhanced. Its long-acting properties allow it to continuously stimulate the anterior pituitary gland to release growth hormone, thereby promoting the synthesis and secretion of insulin-like growth factor-1. Compared to short-acting GRF analogues, temorelin has a significantly prolonged half-life, giving it unique advantages in studying growth hormone axis function, assessing growth hormone-related metabolic effects, and exploring the role of growth hormone in lipid metabolism and body composition regulation.

Due to its potent and sustained growth hormone-releasing effect, temoorelin is a preferred choice for researchers in endocrinology, metabolism, obesity, and body composition regulation. Its well-defined dose-dependent effect makes it a standardized and predictable key tool in preclinical models of HIV-related lipodystrophy, metabolic syndrome, and growth hormone deficiency-related metabolic disorders. Compared to direct use of growth hormone, its mechanism of action-physiologically stimulating the pituitary gland to release endogenous growth hormone-makes it more physiologically relevant in studying the regulation of the growth hormone axis.

Tesamorelin Applications:

It binds to the anterior pituitary growth hormone-releasing hormone receptor, stimulating the synthesis and release of growth hormone, thereby promoting the production of insulin-like growth factor-1 and regulating lipid metabolism and body composition. Temorelin is a long-acting growth hormone-releasing factor analog based on the GRF receptor agonist mechanism and is an important tool for studying growth hormone axis function, lipid metabolism regulation, and changes in body composition.

Temorelin is widely used in research on growth hormone axis function, exploration of the mechanisms of lipodystrophy, and studies related to metabolic syndrome. Its well-defined pharmacological mechanism of action provides a high-quality research model for evaluating novel growth hormone-releasing agents, studying the role of growth hormone in lipid metabolism, and exploring growth hormone-related metabolic effects. It is also crucial in evaluating growth hormone replacement therapy strategies and studying the effects of growth hormone on insulin sensitivity and lipid metabolism.

Usage and Storage Methods

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : sterile water for injection or sterile sodium acetate buffer solution with pH 5.0-7.0.

Stability optimization : Sterile water for injection containing 0.1% mannitol

For internal injection : dilute with sterile saline.

Important note : Avoid using alkaline solvents or solvents containing preservatives (such as benzyl alcohol).

Standard preparation procedure :

Solvent preparation :

Solvents were sterile filtered through a 0.22 μm filter membrane.

The solvent temperature was restored to room temperature (20-25℃).

Reconstitution procedure :

Add 1.0 mL of the recommended solvent to a 2 mg vial.

Slowly pour the powder along the bottle wall to avoid direct impact on the powder.

Gently rotate the vial for 3-5 minutes until completely dissolved.

Final concentration: 2 mg/mL (approximately 0.39 mM)

Dispensing and dilution :

Immediately dispense into single-use doses of 20-50 μL using low-adsorption cryovials.

Dilute to the required working concentration with sterile saline or PBS.

Clear labeling: Name, concentration, preparation date, batch number

Strictly avoid light during operation.

Working concentration/dosage reference :

In vitro cell experiments : Commonly used concentration range is 0.1 nM to 1 μM

Animal in vivo experiments : The commonly used dosage range is 50 to 500 μg/kg (subcutaneous injection, administered according to the study protocol).

Example of preparation calculation : If a 1 μM working solution is required, take 2.56 μL of stock solution and add it to 1 mL of culture medium.

Key points to note :

Dissolve gently : Avoid swirling or violent shaking; gently rotate to dissolve.

Strict aseptic technique : Operations are performed within a laminar flow hood, using sterile consumables.

Complete protection from light : Sensitive to light, all steps must be performed under light-protected conditions.

Prepare and use immediately : Stability is limited after reconstitution, so it is recommended to use as soon as possible.

To avoid adsorption : Dilute with a solution containing 0.1% bovine serum albumin or silanized low-adsorption tubes.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Frozen at -20℃, shelf life 24 months

Optimal storage : -80°C (deep freeze), shelf life 36 months.

Strictly protected from light : Must be stored in the original light-proof aluminum foil bag.

Moisture protection : Keep dry, with built-in desiccant.

Reconstituted solution :

immediately after reconstitution for optimal activity.

Short-term storage : Refrigerate at 2-8℃, away from light, for no more than 8 hours.

Repackage and freeze : Store at -20℃ or -80℃ away from light, for no more than 1 week.

Repeated freeze-thaw cycles are strictly prohibited : a maximum of one freeze-thaw cycle.

Transportation conditions :

Freeze-dried powder : transported with dry ice (-78℃)

Short-term shipping : Transported with ice packs at 2-8℃, ensuring delivery within 48 hours.

Packaging : Light-proof aluminum foil bag + vacuum seal + foam insulated box

3. Stability and Processing Standards :

Chemical and physical stability :

It is relatively stable in aqueous solutions with a pH range of 5.0–7.0.

Avoid contact with strong acids, strong alkalis, and oxidizing agents.

Sensitive to mechanical stress (such as violent blowing or vortexing).

Maintenance of bioactivity :

Proper aliquoting and storage at -80°C are key to maintaining long-term activity.

Thaw and dispense the solution slowly on ice before use.

Need anything, please contact us

Hot Tags: tesamorelin 2mg/vial specific reduction of abdominal visceral fat, China tesamorelin 2mg/vial specific reduction of abdominal visceral fat manufacturers, suppliers, factory, AOD9604 Ideal For Competition Prep Peak Weeks, ace 031 1mg, buy aod 9604 pills, peptide cjc ipamorelin, Alternative to GHRP 6, hgh ipamorelin