Gonadorelin 2mg/vial Restore Fertility

Gonadorelin 2mg/bottle core introduction

Natural Gonadotropin-Releasing Hormone | Decapeptide GnRH Agonist 2mg/bottle

Generic name : Gonarelin

English name : Gonadorelin

Sequence : pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

Molecular weight : Approximately 1182.3 Da

Purity : ≥98.0% (HPLC)

Content : 2mg/bottle

Appearance : White lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.

Usage and Storage Guide

Gonadorelin:

Gonareline is a synthetic decapeptide of natural gonadotropin-releasing hormone (GnRH), structurally identical to endogenous GnRH secreted by the hypothalamus. It mimics physiological pulsatile GnRH secretion, acting on GnRH receptors in the anterior pituitary gland to stimulate the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Its short-acting, pulsatile nature makes it valuable for studying hypothalamic-pituitary-gonadal axis function, assessing pituitary responsiveness to GnRH, and exploring reproductive endocrine regulatory mechanisms.

Due to its identical structure and mechanism of action to endogenous GnRH, gonadorelin is widely used in reproductive endocrinology, infertility research, and gonadal function assessment. Compared to long-acting GnRH analogs, its short-acting nature allows it to more accurately mimic physiological pulsatile secretion, providing an ideal tool for studying pituitary-gonadal axis function, assessing gonadotropin reserves, and exploring sex hormone feedback regulation mechanisms.

Gonadorelin Applications:

It binds to GnRH receptors in the anterior pituitary gland, stimulating the synthesis and release of luteinizing hormone and follicle-stimulating hormone, thereby promoting the secretion of sex hormones. Gonarelin is an important tool for studying the function of the hypothalamus-pituitary-gonadal axis, assessing pituitary gonadotropin reserves, and exploring the mechanisms of reproductive endocrine regulation.

Gonarelin is widely used in reproductive endocrinology, infertility mechanism research, and gonadal function assessment. Its well-defined pharmacological mechanism of action provides a high-quality research model for assessing pituitary responsiveness to GnRH, studying sex hormone feedback regulation, and exploring the pathogenesis of reproductive system diseases.

Usage and storage methods

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : sterile water for injection or sterile sodium acetate buffer solution with pH 5.0-7.0.

Stability optimization : Sterile water for injection containing 0.1% mannitol

For internal injection : dilute with sterile saline.

Important note : Avoid using alkaline solvents or solvents containing preservatives (such as benzyl alcohol).

Standard preparation procedure :

Solvent preparation :

Solvents were sterile filtered through a 0.22 μm filter membrane.

The solvent temperature was restored to room temperature (20-25℃).

Reconstitution procedure :

Add 1.0 mL of the recommended solvent to a 2 mg vial.

Slowly pour the powder along the bottle wall to avoid direct impact on the powder.

Gently rotate the vial for 3-5 minutes until completely dissolved.

Final concentration: 2 mg/mL (approximately 1.69 mM)

Dispensing and dilution :

Immediately dispense into single-use doses of 20-50 μL using low-adsorption cryovials.

Dilute to the required working concentration with sterile saline or PBS.

Clear labeling: Name, concentration, preparation date, batch number

Strictly avoid light during operation.

Working concentration/dosage reference :

In vitro cell experiments : Commonly used concentration range is 0.1 nM to 1 μM

Animal in vivo experiments : The commonly used dosage range is 50 to 500 μg/kg (subcutaneous or intravenous injection, administered pulsatilely according to the study protocol).

Example of preparation calculation : If a 1 μM working solution is required, take 0.59 μL of stock solution and add it to 1 mL of culture medium.

Key points to note :

Dissolve gently : Avoid swirling or violent shaking; gently rotate to dissolve.

Strict aseptic technique : Operations are performed within a laminar flow hood, using sterile consumables.

Complete protection from light : Sensitive to light, all steps must be performed under light-protected conditions.

Prepare and use immediately : Stability is limited after reconstitution, so it is recommended to use as soon as possible.

To avoid adsorption : Dilute with a solution containing 0.1% bovine serum albumin or silanized low-adsorption tubes.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Frozen at -20℃, shelf life 24 months

Optimal storage : -80°C (deep freeze), shelf life 36 months.

Strictly protected from light : Must be stored in the original light-proof aluminum foil bag.

Moisture protection : Keep dry, with built-in desiccant.

Reconstituted solution :

immediately after reconstitution for optimal activity.

Short-term storage : Refrigerate at 2-8℃, away from light, for no more than 8 hours.

Repackage and freeze : Store at -20℃ or -80℃ away from light, for no more than 1 week.

Repeated freeze-thaw cycles are strictly prohibited : a maximum of one freeze-thaw cycle.

Transportation conditions :

Freeze-dried powder : transported with dry ice (-78℃)

Short-term shipping : Transported with ice packs at 2-8℃, ensuring delivery within 48 hours.

Packaging : Light-proof aluminum foil bag + vacuum seal + foam insulated box

3. Stability and Processing Standards :

Chemical and physical stability :

It is relatively stable in aqueous solutions with a pH range of 5.0–7.0.

Avoid contact with strong acids, strong alkalis, and oxidizing agents.

Sensitive to mechanical stress (such as violent blowing or vortexing).

Maintenance of bioactivity :

Proper aliquoting and storage at -80°C are key to maintaining long-term activity.

Thaw and dispense the solution slowly on ice before use.

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