Semax 5mg/vial Significantly Enhances Cognitive Function, Improves Mental Performance, And Promotes Neuroprotection.

Semax 5mg/bottle core introduction

Neuroprotective peptides | Brain-derived neurotrophic factor mimic peptides 5mg/vial

Generic name : Smith

Sequence : Met-Glu-His-Phe-Pro-Gly-Pro

Molecular weight : Approximately 813.9 Da

Purity : ≥99.0% (HPLC)

Appearance : White lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.

Usage and Storage Guide

Smecta is a synthetic peptide derived from a fragment of adrenocorticotropic hormone (ACTH) and possesses potent neuroprotective, neurotrophic, and cognitive-enhancing properties. Unlike traditional neuropharmaceuticals, Smecta enhances neuroplasticity and improves the brain's antioxidant defense mechanisms by regulating the expression of brain-derived neurotrophic factor (BDNF). Its unique pleiotropic effects make it valuable for studying neurodegenerative diseases, ischemic brain injury, cognitive impairment, and the mechanisms of learning and memory. Its ability to effectively cross the blood-brain barrier has also attracted significant attention in central nervous system research.

Due to its significant enhancement of cognitive function and neuroprotective properties, many neuroscience researchers and researchers in the field of cognitive enhancement prefer to use Smecta. It does not act through traditional hormone receptors, but rather by affecting the nerve growth factor system and neurotransmitter metabolism, thus avoiding complex systemic side effects. Its ability to improve learning, memory, and attention, as well as its potential anti-stress and anti-anxiety effects, make it a highly effective research tool in studying cognitive enhancement, neurorehabilitation, and models of mental illness.

Smex enhances neuroplasticity, promotes BDNF expression, improves learning and memory function, and provides neuroprotective effects. It is a synthetic neuropeptide based on the ACTH fragment, exhibiting significant effects in regulating central nervous system function and enhancing cognitive performance.

Smecta is widely used in neuroscience, cognitive psychology, and neuropharmacology research. Its ability to regulate multiple neurotransmitter systems, as well as its promoting effects on neuronal survival and synaptic plasticity, makes it a valuable and highly specific molecular tool for studying Alzheimer's disease, Parkinson's disease, post-stroke recovery, traumatic brain injury, and cognitive enhancement strategies.

Usage and storage methods

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : sterile water for injection or sterile physiological saline (0.9% NaCl)

For intranasal administration studies : sterile isotonic saline or a dedicated sterile nasal solvent (pH 5.5-7.0).

For animal experiments : dissolve in sterile physiological saline.

Standard preparation procedure :

Solvent preparation :

Solvents were sterile filtered through a 0.22 μm filter membrane.

Return the solvent to room temperature (20-25℃).

Reconstitution procedure :

Add 1.0 mL of the recommended solvent to a 5 mg vial.

Pour slowly along the bottle wall, avoiding violent impact.

Gently rotate the vial for 2-3 minutes until completely dissolved.

Final concentration: 5 mg/mL (approximately 6.1 mM)

Separate and store :

Immediately dispense into single-use doses using low-adsorption centrifuge tubes.

Clear labeling: Product name, concentration, preparation date, batch number

Store away from light

Working concentration/dosage reference :

In vitro cell experiments : Commonly used concentration range is 0.1 μM to 10 μM

Animal in vivo experiments : The commonly used dosage range is 50 μg/kg to 300 μg/kg

Example of preparation calculation : If a 100 μM working solution is required, take 16.4 μL of stock solution and add it to 1 mL of culture medium.

Key points to note :

Aseptic technique : Preparation is completed inside a biosafety cabinet.

Light avoidance requirement : Sensitive to light, operation must be carried out in the dark.

Solubility : Soluble well in water and physiological saline.

Avoid adsorption : Use consumables with low adsorption properties.

Prepare and use immediately : It is recommended to use immediately after reconstitution.

Nasal formulation : When used in intranasal drug delivery studies, a dedicated sterile nasal solvent must be used.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Frozen at -20℃, shelf life 24 months

Optimal storage : -80°C (deep freeze), shelf life 36 months.

Light protection requirement : Store in the original aluminum foil bag away from light.

Moisture-proof storage : Built-in desiccant, relative humidity ≤60%.

Reconstituted solution :

immediately after reconstitution for optimal activity.

Short-term storage : Refrigerate at 2-8℃ for no more than 12 hours.

Repackaging and freezing : Repack and freeze at -20℃ for no more than 7 days.

Freeze-thaw cycle strictly prohibited : a maximum of one freeze-thaw cycle is allowed.

Transportation conditions :

Cold chain transportation : Dry ice transportation (below -78℃)

Short-term transportation : 2-8℃ ice pack transportation, not exceeding 24 hours.

Packaging standard : Light-proof aluminum foil bag + vacuum packaging + insulated box

Transportation labeling : Clearly marked "biological products," "low temperature," and "protect from light."

3. Stability Management :

Temperature stability :

-80℃: >3 years

-20℃: >2 years

2-8℃: ≤12 hours (solution)

Room temperature: ≤4 hours (solution)

Chemical stability :

Optimal pH range: 5.0-7.5

Avoid strong acid and strong alkaline environments.

Light stability :

Sensitive to ultraviolet light

The entire process must be carried out in the dark.

Microbial stability :

Strict aseptic technique

Use sterile solvents and consumables

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