Selank 5mg/vial Effectively Relieves Anxiety, Stabilizes Mood, And Enhances Cognitive Function

Selank 5mg/bottle core introduction

Neuromodulatory heptapeptide | Centrally active peptide 5mg/bottle

Common name : Slank

English name : Selank

Sequence : Thr-Lys-Pro-Arg-Pro-Gly-Pro

Molecular weight : Approximately 751.9 Da

Purity : ≥98.5% (HPLC)

Content : 5mg/bottle

Appearance : White lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.

Usage and Storage Guide

Selank:

Slanc is a synthetic heptapeptide, an analogue of endogenous thymopoietin metabolic fragments, exhibiting enhanced enzymatic stability and bioavailability. As a neuroactive peptide, it has been shown in research models to potentially regulate neurotransmitter systems, including GABAergic, serotonergic, and glutamatergic systems, thereby potentially influencing stress responses, anxiety-like behaviors, and cognitive function. Compared to traditional benzodiazepines, its peptide structure and potential for multi-neurotransmitter regulation make it a valuable tool molecule for studying the neurobiological mechanisms related to anxiety, learning and memory, and stress adaptation.

Due to its potential central nervous system modulatory properties, slanc is frequently used by researchers in neuroscience, behavioral pharmacology, and psychoneuroimmunology. Compared to some drugs with single mechanisms of action and well-defined side effects, its potential for multi-target regulation makes it a standardized research agent in animal models for studying complex behavioral states, evaluating novel neuromodulation strategies, and exploring the effects of neuropeptides on mood and cognitive function. Its application in stress models, anxiety behavior assessments, and learning and memory tests provides a feasible approach to exploring the physiological functions of neuropeptides.

Selank Applications:

As an investigational neuropeptide, it is used in specific experimental models to assess its potential impact on the function of the neurotransmitter system and the resulting behavioral effects. It is primarily used to study the mechanisms of behavioral and emotional pathways related to anxiety, learning, memory, and stress responses.

It has been applied in studies of anxiety and depression-like animal behavior models, learning and memory ability tests, chronic stress models, and neuroimmune regulation. Its well-defined chemical structure and relative stability provide a standardized research tool for assessing its potential effects on central nervous system function and behavior under controlled experimental conditions.

Usage and Storage Methods

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : sterile water for injection or sterile buffer (such as PBS) with pH 5.5-7.0.

For internal injection : dilute with sterile saline.

For intranasal administration in research : it can be prepared with sterile isotonic saline.

Important note : Avoid using strong acids, strong bases, or solutions containing organic solvents.

Standard preparation procedure :

Solvent preparation :

Use solvents that have been sterilely filtered through a 0.22 μm filter membrane.

The solvent temperature was restored to room temperature (20-25℃).

Reconstitution procedure :

Add 1.0 mL of the recommended solvent to a 5 mg vial.

Pour slowly along the bottle wall to avoid direct impact on the powder.

Gently rotate the vial for 3-5 minutes until completely dissolved, avoiding vigorous shaking that may create bubbles.

Final concentration: 5 mg/mL (approximately 6.65 mM).

Dispensing and dilution :

Immediately dispense into single-use doses of 10-50 μL using low-adsorption cryovials.

Dilute to the required working concentration with sterile saline, PBS, or a suitable carrier solution.

Clearly label: name, concentration, preparation date, batch number.

Working concentration/dosage reference :

In vitro cell experiments : The commonly used concentration range is 0.1 μM to 10 μM, and preliminary experiments need to be performed to optimize the concentration based on the specific cell type and experimental purpose.

Animal in vivo experiments :

Intraperitoneal/subcutaneous injection : The usual dosage range is 50 to 300 μg/kg.

Intranasal administration : The concentration and dosage need to be determined based on the specific research model, and are usually low doses.

It is strongly recommended that the precise dosage be determined based on preliminary experiments, the specific route of administration, and animal ethics requirements.

Example of preparation calculation : If a 100 μM working solution is required, take about 15 μL of stock solution and add it to 1 mL of culture medium or solvent.

Key points to note :

Dissolve gently : Avoid swirling or violent shaking; simply rotate gently to dissolve.

Strict aseptic technique : Operate in a clean bench and use sterile consumables, especially when administering medication internally or intranasally.

Completely avoid light : It is sensitive to light, and all steps must be carried out under light-protected conditions.

Prepare and use immediately : The stability is limited after reconstitution, so it is recommended to use it as soon as possible. After repackaging, store it under the specified conditions.

To avoid adsorption : dilution with a solution containing 0.1% bovine serum albumin or silanized low-adsorption tubes can reduce adsorption on the tube walls.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Freeze at -20℃, shelf life 24 months.

Optimal storage : -80°C deep freeze, shelf life 36 months.

Strictly protected from light : Must be stored in the original light-proof aluminum foil bag.

Moisture protection : Keep dry; contains desiccant.

Reconstituted solution :

Use immediately : For best activity, use immediately after reconstitution.

Short-term storage : Refrigerate at 2-8℃ away from light, for no more than 24 hours.

Repackage and freeze : Store at -20℃ or -80℃ away from light for no more than 1 week.

Repeated freeze-thaw cycles are strictly prohibited : a maximum of one freeze-thaw cycle.

Transportation conditions :

Freeze-dried powder : transported by dry ice (-78℃).

Short-term shipping : 2-8℃ ice pack shipping, ensuring delivery within 48 hours.

Packaging : Light-proof aluminum foil bag + vacuum seal + foam insulated box.

3. Stability and Processing Standards :

Chemical and physical stability :

It is relatively stable in aqueous solutions with a pH of 5.0–7.0.

Avoid contact with strong acids, strong alkalis, and oxidizing agents.

It is sensitive to high temperatures and mechanical stress.

Maintenance of bioactivity :

Proper aliquoting and storage at -80°C are key to maintaining long-term activity.

Thaw and dispense the liquid slowly on ice or under refrigeration before use.

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