MT2 10mg/vial Effectively Promotes Melanin Production in The Skin

MT2 10mg/bottle core introduction

Potent α-MSH analogue | Melanocortin receptor agonist 10mg/vial

Generic name : Melanotan II

English name : Melanotan II

Sequence : Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Molecular weight : Approximately 1024.2 Da

Purity : ≥98.0% (HPLC)

Appearance : White lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.

Usage and Storage Guide

Melanotan II (MT2):

Melanotan II is a synthetic cyclic heptapeptide and a potent, non-selective melanocortin receptor agonist. Compared to natural α-melanocyte-stimulating hormone, MT2 exhibits significantly enhanced agonistic activity against receptor subtypes such as MC1R, MC3R, MC4R, and MC5R, with significantly improved metabolic stability. Its unique multi-receptor agonistic properties enable it not only to strongly stimulate melanin synthesis but also to exert complex physiological effects such as promoting libido and regulating appetite and energy metabolism. These broad effects make it a versatile research tool for studying skin pigmentation, neuroendocrine regulation, and energy balance.

Due to its recognized potent melanin-promoting effect and potential central effects, MT2 is favored by researchers in pigment metabolism, photoprotection, and neuroendocrinology. Unlike single-target agonists, its multi-receptor agonist properties allow it to simultaneously activate multiple signaling pathways, providing a unique perspective for studying the physiological functions of the melanocortin system. Its regulatory effects on sexual behavior and appetite also make it valuable in understanding the mechanisms by which neuropeptides regulate complex behaviors.

Melanotan II (MT2) Applications:

Melanotan II nonselectively activates melanin receptors, strongly promoting melanin synthesis in skin melanocytes, and may affect feeding behavior and sexual function through central mechanisms. It is a synthetic peptide based on a multi-target regulatory mechanism of melanin receptors and is an important tool for studying skin photobiology and neuroendocrine interactions.

Melanotan II is widely used in basic research on skin pigment metabolism, ultraviolet protection mechanisms, and the physiological functions of the melanocortin system. Its multiple receptor agonist effects provide complex experimental models for exploring the skin's adaptive response to photodamage, studying the neural regulation of appetite and energy expenditure, and assessing the effects of neuropeptides on reproductive behavior. It is also widely used in related receptor pharmacology and behavioral studies.

Usage and storage methods

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : sterile water for injection or sterile phosphate buffer with pH 7.0-7.5

Stability optimization : Sterile saline containing 0.1% bovine serum albumin (BSA) (reduces adsorption)

For subcutaneous injection : dilute with sterile saline.

Standard preparation procedure :

Solvent preparation :

Solvents were sterile filtered through a 0.22 μm filter membrane.

Return the solvent to room temperature (20-25℃).

Avoid using solvents containing preservatives.

Reconstitution procedure :

Add 1.0 mL of the recommended solvent to a 10 mg vial.

Slowly pour the liquid along the bottle wall to avoid direct impact on the lyophilized powder.

Gently rotate the vial for 3-5 minutes until completely dissolved.

Final concentration: 10 mg/mL (approximately 9.8 mM)

Dispensing and dilution :

Immediately aliquot into 20-50 μL portions using low-absorption cryovials.

Dilute to working concentration with physiological saline or PBS containing 0.1% BSA.

Clear labeling: Product name, concentration, preparation date, batch number

Working concentration/dosage reference :

In vitro cell experiments : Commonly used concentration range is 0.1 nM to 1 μM

Animal in vivo experiments : The commonly used dosage range is 0.1 to 1.0 mg/kg (subcutaneous injection).

Example of preparation calculation : If a 1 μM working solution is required, take 0.102 μL of stock solution and add it to 1 mL of culture medium.

Key points to note :

Dissolve gently : Avoid violent shaking or swirling to prevent damage to the ring structure.

Aseptic technique : All preparation steps are completed within a biosafety cabinet.

Strictly avoid light : Sensitive to light, operation must be carried out in complete darkness.

Avoid adsorption : Use solutions containing carrier proteins to reduce adsorption loss.

Prepare and use immediately : It is recommended to use within 1 hour after reconstitution.

Concentration control : Avoid preparing excessively low concentrations to prevent accelerated degradation.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Frozen at -20℃, shelf life 24 months

Optimal storage : -80°C (deep freeze), shelf life 36 months.

Light protection requirement : Store in the original aluminum foil bag away from light.

Moisture-proof storage : Built-in desiccant, relative humidity ≤50%.

Reconstituted solution :

immediately after reconstitution for optimal activity.

Short-term storage : Refrigerate at 2-8℃ for no more than 8 hours.

Repackaging and freezing : Repack and freeze at -20℃ for no more than 72 hours.

Freeze-thaw limit : A maximum of 1 freeze-thaw cycle is allowed.

Transportation conditions :

Cold chain transportation : Dry ice transportation (below -78℃)

Packaging standard : Light-proof aluminum foil bag + vacuum seal + insulated box

Shipping labeling : Clearly marked "Bioactive Peptides", "Low Temperature", and "Protect from Light".

3. Stability Management :

Temperature stability :

-80℃: >3 years

-20℃: >2 years

2-8℃: ≤8 hours (solution)

Room temperature: ≤2 hours (solution)

Chemical stability :

Optimal pH range: 6.5-7.5

Avoid environments with strong acids, strong alkalis, and oxidizing agents.

Light stability :

Highly sensitive to ultraviolet light

Strict light avoidance is required throughout the entire process.

Physical stability :

Avoid violent tremors

Avoid repeated freeze-thaw cycles

Avoid high temperature processing

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