HGH 176/191 fragment 2mg/vial core introduction
Pharmaceutical-grade peptide formulation | Chinese-made growth hormone fragments (Growth Hormone Fragment 176-191 )
Chemical name : H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH
Sequence : YLRIVQCRSVEGSCGF
CAS No. **: 66304-57-2
Specification : 2mg/bottle
Dosage form : Lyophilized powder for injection
Molecular weight : 1815.1 Da
Appearance : White freeze-dried lumpy powder
Purity : ≥98% (HPLC detection)
Storage conditions : Store at -20℃ away from light.
Core Effects
The HGH 176-191 fragment is a C-terminal modified fragment of growth hormone , which is widely used in lipid metabolism research, obesity treatment and body composition improvement due to its selective lipolysis activity .
✅Selective lipolysis mechanism :
Receptor targeting : Preserves the lipolytic activity of growth hormone while eliminating its growth-promoting effects.
Fat-targeting : Specifically promotes cAMP production in adipocytes, stimulating lipolysis.
Neutral glucose metabolism : does not affect insulin levels and blood glucose stability.
✅Quality advantages of Chinese manufacturing :
Purity Guaranteed : Solid-phase synthesis process, purity ≥98%, single impurities ≤0.1%.
Sequence accuracy : 100% correct amino acid sequence
Disulfide bonds are correctly formed : Cys7-Cys14 disulfide bond formation rate ≥ 99%.
✅Global supply assurance :
Cold chain logistics : -20℃ cold chain transportation throughout the entire process to ensure product stability.
Multi-warehouse delivery : Regional warehouses are established in China, Europe, America, and the Asia-Pacific region, ensuring delivery within 7 days.
Customs clearance support : Professional document preparation ensures smooth customs clearance worldwide.
Production process and quality assurance
1. Advanced synthesis process :
Solid-phase synthesis : The Fmoc solid-phase synthesis strategy was adopted, with a condensation efficiency >99.5%.
Disulfide bond formation : Air oxidation method, disulfide bond accuracy ≥ 99%.
Purification process : Preparative HPLC purification, gradient elution, collection of the main peak.
2. Strict quality control standards :
Chemical purity :
Main component content: 98.0%~102.0%
Related substances: Single impurity ≤0.1%, total impurities ≤0.5%
Acetic acid content: ≤10.0% (ion chromatography)
Biological activity :
Fat breakdown test: potency not less than 90% of the standard.
Receptor binding assay: Meets quality standards
3. Stability data :
Long-term stability : Stored at -20℃ for 24 months, all indicators meet the requirements.
Accelerated testing : After being stored at 25°C for 6 months, the purity decreased by ≤2.0%.
Stability in use : After reconstitution, store at 2-8℃ for 7 days; purity ≥95%.
Scientific Research Applications and Clinical Prospects
1. Mechanism of action study :
Lipolysis : Promotes lipolysis through the cAMP-PKA pathway
Receptor selectivity : selective activation of GH receptors in adipocytes
Metabolic regulation : regulating the expression of lipid metabolism-related genes
2. Research and application areas :
Obesity research : Pathogenesis and treatment of obesity
Metabolic diseases : A study of type 2 diabetes and metabolic syndrome
Sports Medicine : Research on Fat Loss and Body Composition Improvement in Athletes
3. Preclinical data :
Fat reduction : Animal experiments show a significant reduction in body fat.
Highly selective : Primarily targets abdominal and visceral fat.
Good safety profile : Does not affect blood sugar and insulin levels.
China's manufacturing quality advantages
1. Advantages in manufacturing process :
Synthesis technology : Microwave-assisted solid-state synthesis with high condensation efficiency.
Folding control : Proper folding of disulfide bonds ensures biological activity.
Purification process : Preparative HPLC purification, purity ≥ 98%.
2. Quality Assurance System :
Compliant with standards : Meets Chinese Pharmacopoeia, USP, and EP standards.
Stability study : Complete a comprehensive stability investigation.
Batch consistency : Strict process control ensures consistency between batches.
3. Global supply network :
Production Base : GMP-compliant production base in China
Distribution network : A global distribution and cold chain logistics network
Registration support : Supports registration applications from countries around the world.
Why choose the Chinese-made HGH 176-191 fragment ?
Selective lipolysis : Retains lipolysis activity while eliminating growth-promoting effects.
Precise sequence : 100% correct amino acid sequence, disulfide bonds correctly formed.
Exceptional purity : Over 98% high purity, with strict quality control.
Stable supply : A complete supply chain ensures timely and reliable delivery.
Summary
Made in China, HGH 176-191 fragment 2mg lyophilized powder for injection represents a high-quality standard for selective lipolysis peptides . Through advanced synthesis processes, rigorous quality control, and a stable supply system , it provides high-quality, highly active research tools for global obesity and metabolic disease research . Choosing Made in China means choosing research-grade quality and reliable assurance .
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