Dermorphin 5mg/vial Potential For Potent Analgesia

Dermorphin 5mg/vial Potential For Potent Analgesia
Product Introduction:
Dermorphin is a naturally occurring opioid peptide whose core benefit lies in its potentially potent analgesic effect. It binds with high affinity to and activates μ-opioid receptors, producing a morphine-like analgesic effect, but studies suggest its potency may be even stronger. Due to its unique structure, it does not readily cross the blood-brain barrier, which may help achieve peripheral analgesia while reducing the risk of central nervous system-related side effects such as addiction and respiratory depression. It shows research potential in the management of intractable pain.
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Description
Technical Parameters

Dermorphin 5mg/bottle core introduction

High-purity corticomerol raw material | Made in China, potent μ-opioid receptor agonist 5mg/bottle

Generic name : Piperamide

English name : Dermorphin

Amino acid sequence : H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂

CAS No .: 77614-16-5

Molecular formula : C₄₀H₅₀N₈O₁₀

Molecular weight : 802.89 g/mol

Purity : ≥98.0% (HPLC)

Appearance : White lyophilized powder

Storage : Freeze at -20℃, protect from light, and store in a dry place.


Usage and Storage Guide

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : 1% aqueous acetic acid solution or 0.1M hydrochloric acid solution

Secondary solvent : Sterile water for injection (please pay attention to solubility).

For cell experiments : dissolve in a small amount of dilute acid first, then dilute with PBS or culture medium.

Standard preparation procedure :

Solvent preparation :

Return the 1% acetic acid solution or sterile water to room temperature.

It is recommended to add 0.1% bovine serum albumin (BSA) to reduce adsorption.

Reconstitution procedure :

Add 1.0 mL of solvent to a 5 mg vial.

Gently rotate the vial to dissolve it completely.

Final concentration: 5 mg/mL (approximately 6.2 mM)

Separate and store :

Immediately dispense into 10-20 μL portions.

Label concentration, date, batch

Preparation of working solution :

In vitro cell experiments : working concentration 0.1-10 nM

Animal studies : Recommended dose 1-10 μg/kg

Note : Avoid repeated freeze-thaw cycles; use fresh aliquots for each experiment.

Key points to note :

Dissolving tips : An acidic environment (pH 3-4) is conducive to dissolution.

Avoid adsorption : Use pipes with low adsorption properties

Aseptic technique : Strict aseptic technique must be maintained during the preparation process.

Use immediately : Use within 1 hour after reconstitution.

Safety precautions : Wear gloves and a mask during operation.

2. Storage conditions :

Unreconstituted lyophilized powder :

Long-term storage : Store frozen at -20℃, shelf life 24 months

Optimal storage : Store frozen at -80°C; shelf life 36 months.

Light protection requirement : Store in the original aluminum foil bag away from light.

Reconstituted solution :

Use immediately : Best used immediately after preparation.

Short-term storage : Refrigerate at 2-8℃ for no more than 4 hours.

Long-term storage : Aliquot and freeze at -20℃ for no more than 1 month.

Transportation conditions :

Freeze-dried powder : transported with dry ice (below -78℃).

Short-term transportation : Ice pack transportation (2-8℃)

Light-proof packaging : Light-proof materials must be used.

3. Preparation details guide :

Solvent selection principles :

Prefer acidic solvents

Avoid using alkaline buffer solutions.

Recommended 1% acetic acid solution

Dissolution method :

Add solvent slowly

Gentle rotational dissolution

Avoid violent oscillations

Concentration control :

Stock solution concentration 5 mg/mL

Prepare working solution fresh each time.

Avoid high dilution storage

Storage tips :

Dispense volume 10-20 μL

Clear and complete markings

Store separately in a sealed container

4. Special Notes :

Biosafety :

Operating in a dedicated fume hood

Avoid direct skin contact

Specialized waste liquid treatment

stability :

It is sensitive to light and needs to be kept away from light.

Sensitive to heat, avoid high temperatures.

Sensitive to enzymes, please store carefully.

Compatibility :

Compatible with acidic solvents

Avoid contact with oxidants

It does not coexist with metal ions


Quality Advantages of Chinese Manufacturers

This product is manufactured by a professional peptide producer in China, strictly adhering to cGMP standards, and its quality has reached the international advanced level.

✅Advanced Synthesis Technology :

Fmoc solid-phase synthesis : using microwave-assisted technology

D-Amino Acid Proprietary Technology : Precise Introduction of D-Alanine

Mass production : batch sizes up to 10 grams

Fully automated control : ensuring synthesis accuracy

✅Strict quality control :

Purity testing :

HPLC purity ≥ 98.0%

Chiral purity D-Ala ≥ 99.5%

Single impurity ≤ 0.5%, total impurities ≤ 2.0%

Structural confirmation :

MALDI-TOF MS mass spectrometry analysis

Amino acid composition analysis

Sequence verification

Bioactivity :

GPCR activity detection

IC₅₀≤0.1nM

Selective Validation

Security check :

Bacterial endotoxin <10 EU/mg

Passed sterility test

Heavy metals <10ppm

Physicochemical properties :

Moisture content ≤ 5.0%

Peptide content ≥ 80.0%

Complete solubility

✅Stability Guaranteed :

Accelerated testing : Stable for 3 months at 40℃/75%RH

Long-term test : Stable at -20℃ for 24 months

Photostability : Stable under light-protected conditions

Thermal stability : Stable under refrigeration conditions

✅Professional Packaging :

Vial : Amber-colored light-blocking glass

Sealing system : Fluorinated butyl rubber stopper

Nitrogen purging protection : to prevent oxidation

Individual packaging : Individual aluminum bag + desiccant

Complete tags : Complete information in both Chinese and English

✅Technical Support :

Provide complete technical documentation

Including COA, MSDS

Custom synthesis service

Application technical support

 

Need anything, please contact us

WhatsApp

+852 4671 8216

Telegram

Allenraws

Email

Allenraws810@gmail.com

product-1268-769

 

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