Description

Technical Parameters

SR9011 (SR-9011) Core Introduction

Research -Grade Compound | SR9011 (REV-ERBα Agonist) Metabolic Regulator

Chemical name : (2S)-N-(2-chlorophenyl)-3-((4-chlorophenyl)sulfonyl)-2-((2,2-difluoroethyl)amino)propionamide

CAS number : 1379686-29-5

Molecular formula : C₁₇H₁₅Cl₂F₂N₂O₃S

Molecular weight : 421.28

Appearance : White to off-white crystalline powder

Purity : ≥98% (HPLC)

Core Effects

SR9011 is a potent REV-ERBα agonist . Due to its unique circadian rhythm regulation and metabolic enhancement effects , it is widely used in metabolic disease research, exercise endurance improvement, and exploration of circadian clock mechanisms .

✅ Metabolic rate significantly improved :

Activate the REV-ERBα pathway , increasing basal metabolic rate by 20-30%

Promote fatty acid oxidation and target the reduction of visceral fat

✅ Biorhythm Optimization :

Reset circadian clock gene expression and improve sleep-wake cycles

Enhance mitochondrial function and improve energy metabolism efficiency

✅ Increased exercise endurance :

Increase VO₂ max and aerobic endurance by 40-60%

Reduce exercise fatigue and prolong exhaustion time

Usage Protocol

1. Dosage regimen :

Metabolic studies : 10-20 mg/kg/day, oral gavage or mixed feed

Endurance studies : 15-25 mg/kg/day, administered 1 hour before training

Rhythm study : 5-10 mg/kg/day, fixed-time dosing

2. Dosage :

Oral administration :

Oral administration : Normal saline or 5% DMSO solution

In- feed administration : Evenly mix in standard feed

Dose time :

Morning medication : simulating natural rhythm activation

Pre- training medication : Best taken 1 hour before exercise

Treatment cycle :

Short-term effects : 1-2 weeks

Long-term adaptation : 4-8 weeks

3. Monitoring indicators :

Metabolic markers :

Oxygen uptake (VO₂) and carbon dioxide production (VCO₂)

Respiratory Quotient (RQ) and Energy Expenditure

Sports Performance :

Treadmill endurance test

Swimming time to exhaustion

Molecular markers :

REV-ERBα target gene expression (Bmal1, Clock)

Mitochondrial biogenesis markers (PGC-1α, NRF1)

Storage Guidelines

1. Raw material storage :

Temperature : -20°C for long-term storage, 2-8°C for short-term use

Humidity : Relative humidity ≤ 30%, desiccant protection

Light : Store away from light, in brown glass bottle or wrapped in aluminum foil

Stability : 24 months at -20°C, 6 months at 2-8°C

2. Solution preparation :

Solvent Selection :

Preferred : 5% DMSO + 40% PEG300 + 55% saline

Alternative : 5% Tween-80 + saline

Prepare and use immediately : Store the prepared solution at -20°C for ≤7 days

Avoid repeated freeze-thaw cycles: aliquot for single use

3. Transport Conditions :

Low temperature transport : Dry ice transport (-78°C) or ice pack insulation (2-8°C)

Shockproof packaging : foam box + shockproof material protection

Fast delivery : Delivery within 48 hours to ensure activity

Why choose SR9011 ?

The first REV-ERBα agonist with a unique mechanism and irreplaceable efficacy

Multiple metabolic benefits , improving metabolism and exercise performance simultaneously

High scientific research value , innovative tool for biorhythm and metabolism research

Quality Assurance :

GMP -compliant production , each batch HPLC purity tested (≥98% )

Third-party laboratory report (COA) is included with the product

Microbial limit testing to ensure safety

Worldwide Shipping :

Original sealed packaging , moisture-proof and light-proof

Private delivery , no logo on the outer packaging

Temperature -controlled transportation to ensure stability

Conclusion

SR9011 is an important tool for metabolic research and exercise science , particularly suitable for studying the mechanisms of metabolic syndrome, improving exercise endurance, and regulating biological rhythms . The recommended dose is 10-25mg/kg/day .

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