Description

Technical Parameters

GW0742 (GW-0742) Raw Material Powder Core Introduction

Research -grade ingredient | GW0742 (GW-0742) PPARβ/δ agonist

Chemical Name : (2-Methyl-4-((4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazol-5-yl)methylthio)phenoxy)acetic acid

CAS number : 317318-84-6

Molecular formula : C₂₁H₁₈F₃NO₃S₂

Molecular weight : 453.50

Melting point : 145-148°C

Appearance : White to off-white crystalline powder

Purity : ≥98% (HPLC)

Core Effects

GW0742 is a highly selective PPARβ/δ agonist . Due to its excellent fatty acid oxidation and metabolic regulation , it is widely used in metabolic disease research, exercise endurance improvement, and cardiovascular protection mechanism exploration .

✅ Accelerated fatty acid oxidation :

Activates the PPARβ/δ pathway and significantly enhances fatty acid β-oxidation capacity

Lower blood lipid levels and reduce visceral fat accumulation

✅ Enhanced endurance performance :

Increase mitochondrial biogenesis and improve aerobic endurance by 30-50%

Reduce lactic acid accumulation and delay exercise fatigue

✅ Cardiovascular protection :

Improve vascular endothelial function and reduce the risk of atherosclerosis

Anti-inflammatory and antioxidant effects , protecting myocardial cells

GW0742 (GW-0742) Features

Highly selective agonists :

PPARβ /δ selectivity : 1000-fold higher than PPARα and PPARγ

Specifically activates target gene expression with low risk of side effects

Oral high efficacy :

High oral bioavailability (>80%)

Take once a day , no injection required

Metabolic Stability :

Half-life of 4-6 hours , suitable for single daily administration

Linear pharmacokinetics , dose is proportional to blood concentration

End Product Preparation Guidelines

1. Preparation of oral tablets (10 mg/tablet) :

Example recipe (for 1000 tablets):

GW0742 raw material: 10.0g

Microcrystalline cellulose: 80.0g

Lactose: 50.0g

Cross-linked carboxymethyl cellulose sodium: 8.0g

Magnesium stearate: 2.0g

Preparation process :

Micronization of raw materials : D90≤10μm, improving dissolution

Equal amount incremental mixing : gradually mix evenly with the auxiliary materials

Wet granulation : granulate with appropriate amount of purified water and dry at 50°C

Tableting : 8mm die, 8-10kN pressure tableting

Film coating : Gastro-soluble film coating for enhanced stability and palatability

2. Quality Control Standards :

Content uniformity : RSD≤3% (HPLC method)

Dissolution rate : ≥85% in 30 minutes (paddle method, 50 rpm)

Related substances : Single impurity ≤ 0.5%, total impurities ≤ 1.0%

Why choose GW0742 raw material ?

Highly selective PPARβ/δ agonist , research tool compound

Multiple metabolic benefits , dual regulation of lipid metabolism and sugar metabolism

Broad research areas , including multidisciplinary applications in metabolism, exercise, and cardiovascular

Quality Assurance :

GMP -compliant production , each batch HPLC purity tested (≥98% )

Third-party laboratory report (COA) is included with the product

Microbial limit testing to ensure safety

Worldwide Shipping :

Original sealed packaging , moisture-proof and light-proof

Private delivery , no logo on the outer packaging

Temperature- stable transportation to ensure product stability

Conclusion

GW0742 is an ideal tool compound for research into the PPARβ/δ signaling pathway , particularly suitable for studying the mechanisms of metabolic diseases, exploring the mechanisms of improving exercise endurance, and studying cardiovascular protection . The research dose is 3-10 mg/kg/day .

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