Description

Technical Parameters

Yohimbine HCl (Yohimbine Hydrochloride) Raw Material Powder Core Introduction

Pharmaceutical Grade Ingredients | Yohimbine Hydrochloride (α2-adrenergic receptor antagonist )

Chemical Name : 17α-Hydroxy-yohene-16α-carboxylic acid methyl ester hydrochloride

CAS number : 65-19-0

Molecular formula : C₂₁H₂₆N₂O₃·HCl

Molecular weight : 390.91

Melting point : 288-290°C (decomposition)

Appearance : White or off-white crystalline powder

Purity : ≥98% (HPLC)

Core Effects

Yohimbine hydrochloride is a selective α2-adrenergic receptor antagonist . Due to its unique fat mobilization and blood flow enhancement properties , it is widely used for localized fat reduction, sexual function improvement, and athletic performance enhancement .

✅ Targeted fat breakdown :

Blocks α2-adrenergic receptors to promote lipolysis in stubborn fat areas

Enhance the effect of catecholamines and increase basal metabolic rate

✅ Blood flow enhancement effect :

Dilate peripheral blood vessels and improve local blood circulation

Promote nutrient delivery and accelerate muscle recovery

✅ Improved sexual function :

Central effect , enhancing libido and erectile function

Peripheral vasodilation , improving erection hardness

✅ Advantages :

Targeting stubborn fat , especially in areas with high α2 receptor expression

Multiple physiological benefits , including comprehensive effects of fat loss, energy increase, and sexual function improvement

End Product Preparation Guidelines

1. Preparation of external fat reduction gel (2.5%) :

Recipe example (100g preparation):

Yohimbine HCl raw material: 2.5g

Carbomer 940: 1.0g

Propylene glycol: 10.0g

Ethanol: 40.0g

Menthol: 0.5g (enhanced penetration)

Triethanolamine: appropriate amount (to adjust pH)

Purified water: add to 100g

Preparation process :

Carbomer dispersion : Disperse carbomer in water and swell for 24 hours

Active ingredient dissolution : A mixture of ethanol and propylene glycol dissolves yohimbine

Mixing and homogenization : slowly mix the two phases and stir with a homogenizer

pH adjustment : Triethanolamine to adjust pH to 5.0-6.0

Filling and packaging : aluminum tube or pump bottle packaging

Quality Control :

Content uniformity : RSD≤5% (HPLC test)

Transdermal absorption rate : Franz diffusion cell method evaluation

Stability : 3 months at 40°C/75%RH accelerated test

2. Oral tablet preparation (5 mg/tablet) :

Example recipe (for 1000 tablets):

Yohimbine HCl raw material: 5.0g

Microcrystalline cellulose: 80.0g

Lactose: 50.0g

Cross-linked carboxymethyl cellulose sodium: 8.0g

Magnesium stearate: 2.0g

Preparation process :

Raw material micronization : D90≤10μm

Incremental mixing : gradually mixing with diluent

Wet granulation : granulate with appropriate amount of purified water and dry at 50°C

Tablet coating : 6mm die tableting, gastric soluble film coating

Quality Control :

Content uniformity : RSD≤3% (UV-HPLC detection)

Dissolution rate : ≥85% in 30 minutes (paddle method, 50 rpm)

Related substances : Single impurity ≤ 0.5%, total impurities ≤ 1.0%

3. Preparation of pre-exercise agent :

Recipe Example (makes 100 servings):

Yohimbine HCl raw material: 2.5g (25mg/serving)

Caffeine: 10.0g (100mg/serving)

L-Tyrosine: 5.0g (50mg/serving)

Seasoning: appropriate amount

Carrier: Add up to 100 parts

Usage Protocol

1. Topical gel :

Application Areas : Abdomen, thighs, buttocks and other stubborn fat areas

Dosage : 2.5% gel, 1-2 times a day, 2-3g each time

Use time : Best effect if used 30 minutes before exercise

Usage cycle : 6-8 weeks of continuous use, 2 weeks of rest

2. Oral tablets :

Fat loss uses :

Dosage: 5-10 mg/time, 2-3 times a day

Time: Take 30 minutes before meals

Cycle: 4-6 weeks, maximum dose not exceeding 20 mg/day

Improved sexual function :

Dosage: 5-10 mg/time, taken as needed

Time: Take 60-90 minutes before activity

3. Pre-exercise agents :

Serving size : 1 serving (contains 25mg of yohimbine)

Take time : 30-45 minutes before exercise

Suitable for : Intermediate to advanced trainers

Why choose Yohimbine HCl ?

Targeting stubborn fat , especially in areas with high α2 receptor expression

Multiple mechanisms of action , comprehensive benefits of fat loss, energy increase, and sexual function improvement

Flexible and diverse dosage forms to meet different application needs

Quality Assurance :

GMP -compliant production , each batch HPLC purity tested (≥98% )

Third-party laboratory report (COA) is included with the goods

Microbial limit testing to ensure safety

Worldwide Shipping :

Original sealed packaging , moisture-proof and light-proof

Private delivery , no logo on the outer packaging

Temperature -controlled transportation to ensure stability

Conclusion

Yohimbine hydrochloride can be formulated into topical, oral, or sports supplements through various formulation processes . It is particularly suitable for localized fat reduction, athletic performance enhancement, and sexual function improvement . The recommended dose is 5-20mg/day .

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