Description

Technical Parameters

Letrozole (letrozole) raw material powder core introduction

Pharmaceutical -grade raw materials | Letrozole, a highly active aromatase inhibitor

Chemical name : 4,4'-(1H-1,2,4-triazol-1-ylmethylene)dibenzonitrile

CAS number : 112809-51-5

Molecular formula : C₁₇H₁₁N₅

Molecular weight : 285.31

Melting point : 183-186°C

Appearance : White or off-white crystalline powder

Purity : ≥98% (HPLC)

Core Effects

Letrozole is a highly active non-steroidal aromatase inhibitor . Due to its potent estrogen suppression and high selectivity , it is widely used in breast cancer treatment, ovulation induction, and estrogen control in steroid cycles .

✅ Potent estrogen suppression :

Reversibly binds to aromatase , inhibiting the conversion of androgens to estrogens

Reduce estradiol levels by more than 98%, effectively controlling estrogen-related side effects

✅ High selectivity advantage :

Specifically inhibits aromatase without affecting the synthesis of other steroid hormones

Does not interfere with adrenal cortical hormone synthesis , safer

✅ Ovulation induction application :

Promote follicle development for the treatment of female infertility

Improve ovulation rate and increase chances of pregnancy

✅ Advantages :

High oral bioavailability (99.9%) and easy to use

Moderate half-life (approximately 48 hours), allowing for once-daily dosing

Well tolerated with low risk of side effects

End Product Preparation Guidelines

1. Preparation of oral tablets (2.5 mg/tablet) :

Example recipe (for 1000 tablets):

Letrozole raw material: 2.5g

Microcrystalline cellulose: 80.0g

Lactose: 50.0g

Cross-linked carboxymethyl cellulose sodium: 8.0g

Magnesium stearate: 2.0g

Preparation process :

Raw material pretreatment : micronization (D90≤10μm)

Equal amount incremental mixing : gradually mix with diluent

Wet granulation : granulate with appropriate amount of purified water and dry in fluid bed at 50°C

Granulation : 20 mesh sieve granules, add flow aids and lubricants

Tableting : 6mm round die, 8-10kN pressure tableting

Film coating : Gastro-soluble film coating to improve stability and palatability

Quality Control :

Content uniformity : RSD≤3% (UV-HPLC detection)

Dissolution rate : ≥85% in 30 minutes (paddle method, 50 rpm)

Related substances : Single impurity ≤ 0.5%, total impurities ≤ 1.0%

2. Preparation Notes :

Raw material characteristics : non-steroidal structure, poor water solubility

Production environment : relative humidity ≤ 40%, moisture-proof treatment

Packaging requirements : Aluminum foil blister packaging, light-proof and moisture-proof

Why choose Letrozole ?

One of the most potent aromatase inhibitors , with significant effects

High selectivity , low risk of side effects

Dual function benefits , can be used for breast cancer treatment and ovulation induction

Quality Assurance :

GMP -compliant production , each batch HPLC purity tested (≥98% )

Third-party laboratory report (COA) is included with the goods

Microbial limit testing to ensure safety

Global Shipping :

Original sealed packaging , moisture-proof and light-proof

Private delivery , no logo on the outer packaging

Temperature -controlled transportation to ensure stability

Conclusion

Letrozole can be manufactured into an oral dosage form using a standard tableting process . It is particularly suitable for breast cancer treatment, ovulation induction, and estrogen control during steroid cycles . The recommended dose is 2.5 mg/day .

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