Description

Technical Parameters

Phenacetin (phenacetin) raw material powder core introduction

Pharmaceutical Grade Ingredients | Phenacetin (Basic Ingredient for Antipyretic and Analgesic )

Chemical name : p-Ethoxyacetanilide

CAS number : 62-44-2

EINECS number : 200-533-0

Molecular formula : C₁₀H₁₃NO₂

Molecular weight : 179.22

Melting point : 134-136°C

Appearance : White crystalline powder

Solubility : slightly soluble in water, easily soluble in ethanol and ether

Core Properties

Phenacetin is a classic antipyretic and analgesic raw material . Due to its excellent antipyretic and analgesic effects , it was once widely used in compound analgesic preparations . Currently, it is mainly used as a pharmaceutical intermediate and raw material for specialty preparations .

✅ Pharmacological properties :

Antipyretic effect : Lowers body temperature by inhibiting prostaglandin synthesis

Analgesic effect : moderate analgesic effect on headaches and neuralgia

Duration of action : The drug's effects can last for 5-6 hours

✅ Metabolic properties :

Liver metabolism : Converted into acetaminophen (paracetamol) in the body

Excretion route : Mainly through urine

Half-life : approximately 1-3 hours

Possible end products and applications

1. Compound analgesic tablets :

Classic compound formula :

Phenacetin: 150 mg

Aspirin: 230 mg

Caffeine: 30mg

Clinical Applications :

Headache relief : for migraines, tension headaches

Neuralgia treatment : used for trigeminal neuralgia and sciatica

Use precautions : Do not use in large quantities for a long time

2. Antipyretic and analgesic granules :

Formulation :

Phenacetin: 100mg/packet

Excipients: sucrose, dextrin, flavoring

Packaging: aluminum-plastic composite film bag

How to use :

Adult dosage : 1-2 packets/time, 3 times/day

Children's dosage : Reduce according to weight

Treatment control : continuous use no more than 3 days

3. External analgesic ointment :

Formulation :

Phenacetin: 3%-5%

Base: Vaseline, lanolin

Penetration enhancers: Azone, propylene glycol

Clinical Applications :

Local analgesia : for muscle pain and joint pain

Directions : Apply to the painful area 2-3 times a day

Advantages : Avoid first-pass effect and reduce systemic side effects

Usage Protocol

1. Dosage regimen :

Usual adult dose :

Single dose: 300-600 mg

Maximum daily dose: no more than 2g

Dosage interval: once every 4-6 hours

Special Populations :

Elderly: Reduce the dose appropriately, 300 mg/time is recommended

Hepatic and renal insufficiency: Use with caution or prohibit use

Children: Not recommended for children under 12 years old

2. Precautions for use :

Contraindications :

Contraindicated in patients with severe hepatic and renal insufficiency

Contraindicated in patients with glucose-6-phosphate dehydrogenase deficiency

Contraindicated in patients allergic to phenacetin

Adverse Reactions :

Long-term use may cause methemoglobinemia

High doses may cause hemolytic anemia

Rare nephrotoxic reactions

3. Drug Interactions :

Synergy :

Combined with aspirin to enhance analgesic effect

Combined with caffeine to enhance analgesic effect

Contraindications :

Avoid co-administration with other drugs that may cause methemoglobinemia

It should not be used concurrently with hepatotoxic drugs

Why choose phenacetin raw material ?

Cost-effectiveness : Low raw material cost and good economic benefits

Mature process : Simple preparation process, easy to produce

Effective : Antipyretic and analgesic effects have been clinically verified over a long period of time

Widely used : Can be used in a variety of dosage forms

Conclusion

Phenacetin is a traditional raw material for the preparation of antipyretic and analgesic drugs . Through various formulation processes , it can be made into oral tablets, granules, and topical preparations . Although its use has been restricted in some countries, it still has significant application value in specific areas. Choosing us ensures reliable raw materials and professional technical support .

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