Description

Technical Parameters

Pinealon® 5mg/bottle core introduction

Pharmaceutical-grade neuropeptides | Chinese-made pineal gland regulatory peptide 5mg/vial

Amino acid sequence : Glu-Asp-Arg

CAS No .: 123308-13-0

Molecular weight : 418.4 Da

Purity : ≥99.5% (HPLC detection)

Appearance : White lyophilized powder

Storage : Store frozen at -20℃ away from light; after thawing, refrigerate at 2-8℃.

Core advantages and functions

Pinealon® is a synthetic bioactive peptide composed of three amino acids , originally isolated from pineal gland extract, and is an important member of the Cytogen family . By regulating circadian rhythms, enhancing antioxidant defense, improving mitochondrial function, and promoting neuroprotection , it has significant scientific value in anti-aging research, prevention of neurodegenerative diseases, circadian rhythm regulation, and stress adaptation , and is a key regulatory molecule in chronobiology and anti-aging research .

✅Core Mechanism of Action :

Circadian rhythm regulation : interacting with the SCN (supracochondrial nucleus) to regulate the expression of circadian rhythm genes.

Antioxidant activation : Enhances the activity of endogenous antioxidant enzymes and reduces free radical damage.

Telomere protection : Regulates telomerase activity and delays cell aging.

Neuroprotection : Promotes the expression of neurotrophic factors and enhances synaptic plasticity.

Immune regulation : balancing the immune response and reducing chronic inflammation.

Metabolic optimization : Improves mitochondrial function and promotes energy metabolism

✅Quality advantages of Chinese manufacturers :

Synthesis process : Microwave-assisted Fmoc solid-phase synthesis method is adopted, which improves reaction efficiency by 30%.

Purification process : Reversed-phase HPLC combined with ion-exchange chromatography, purity ≥ 99.5%.

Chirality control : Strictly ensure L-amino acid configuration, optical purity ≥99.9%.

Activity validation : Dual validation through in vitro antioxidant experiments and in vivo aging models

Stability studies : Accelerated testing at 40℃/75%RH and long-term stability studies completed.

Quality control system : Compliant with ICH guidelines, full-process quality traceability system.

✅Product Features :

High membrane permeability : Small molecular weight, easily crosses the blood-brain barrier

Excellent stability : The lyophilized formulation can be stably stored at -20°C for 24 months.

High safety profile : LD50 > 500 mg/kg, wide safety window.

Synergistic effect : It can work synergistically with anti-aging ingredients such as melatonin and vitamins.

Usage and Storage Guide

1. Reconstitution and preparation :

Recommended solvents :

First choice: Sterile saline

Cell experiments: serum-free DMEM/F12 medium

Animal experiments: physiological saline containing 0.1% BSA

Special Research: Artificial Cerebrospinal Fluid (Neuroscience Research)

Standard configuration :

Pour 1 mL of solvent into the 5 mg vial and gently swirl to dissolve.

A 5 mg/mL stock solution was obtained.

Dilute to the working concentration using the appropriate solvent at a ratio of 1:1000.

Preparation points :

Dissolving time: Gently rotate for 3-5 minutes at room temperature.

Solution properties: Clear and transparent, with no visible particles.

Preparation concentrations: Stock solution concentration 5 mg/mL, working solution concentration 5-50 μg/mL

Contraindications: Avoid strong acids and alkalis, and high-temperature heating.

2. Storage conditions :

Unopened :

Store frozen at -20℃ for 24 months .

-80℃ deep-frozen storage: 36 months

Store in a cool, dry, and airtight container.

Reconstituted :

Stock solution: Store at 4°C and use within one week.

Working solution: Prepare fresh and use immediately ; do not exceed 24 hours at 4°C.

Repackage for single use: can be repackaged to avoid repeated freeze-thaw cycles.

Transportation conditions :

Cold chain transportation (below -20℃)

Vacuum Insulated Packaging

Equipped with temperature monitoring device

Stability parameters :

Temperature: Stable below -20℃

Light exposure: Sensitive to ultraviolet light, requires protection from light.

Humidity: Relative humidity < 60%

pH range: 6.5-7.5 is optimal.

Why choose Pinealon®, made in China?

Technical advantages :

Over 20 years of experience in peptide synthesis

Advanced mass spectrometry analysis technology

A comprehensive biological validation platform

Quality control system that meets international standards

Quality Guarantee :

Chemical purity ≥ 99.5% (HPLC)

Single impurity <0.5%

Endotoxin <1.0 EU/mg

Heavy metals <10 ppm

Moisture content < 3.0%

Optical rotation meets the standard

Application Support :

Provide complete technical documentation

Experimental design and optimization

Data analysis support

Literature research and consulting

Cost -effectiveness :

Mass production reduces costs

Compared to imported products, they have a clear price advantage.

Multiple packaging options

Customized service support

Research and application directions

Anti-aging research :

Biomarker research

Exploring the mechanisms of aging

Life Intervention Research

Healthy aging promotion

Neuroscience research :

Neurodegenerative diseases

circadian rhythm disorder

Improved cognitive function

Sleep quality regulation

Metabolic research :

Improved mitochondrial function

Energy metabolism optimization

Oxidative stress defense

Chronic inflammation control

Clinical translation :

Anti-aging product development

Neuroprotective agent research

Rhythm-regulating drugs

combination therapy

Summarize

Pinealon®, a classic anti-aging peptide , holds significant value in chronobiology and anti-aging research . Chinese manufacturers, through advanced synthesis technology, rigorous quality control, and systematic pharmacological validation , provide researchers worldwide with a high-quality, highly active research tool . Its multi-target regulatory properties offer new insights for the research and intervention of age-related diseases.

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