Description

Technical Parameters

IGF-1 DES 2mg/vial core introduction

Pharmaceutical-grade peptide formulation | Made in China IGF-1 DES (Insulin-like growth factor 1 dealanine variant )

Chemical name : Insulin-like growth factor 1 (1-3, 1-4) deletion variant

Sequence : Tyr-Gly-Pro-Gly-Ser-Ser-Ser-Arg-Arg-... (Amino acids 67-70 are missing)

CAS No .: 128703-91-9

Specification : 2mg/bottle

Dosage form : Lyophilized powder for injection

Molecular weight : 7,471 Da

Appearance : White freeze-dried lumpy powder

Purity : ≥98% (HPLC detection)

Storage conditions : Store at -20℃ away from light.

Core Effects

IGF-1 DES is a highly active variant of insulin-like growth factor that is widely used in muscle growth promotion, tissue repair research, and metabolic regulation due to its unique structural modifications and enhanced bioactivity .

✅Enhanced activity mechanism :

Receptor affinity : Increased affinity for IGF-1 receptors, decreased EC50 value.

Protein binding : It does not bind to IGF-binding proteins, thus improving bioavailability.

Local action : Primarily acts at the injection site, with minimal systemic side effects.

✅Quality advantages of Chinese manufacturing :

Purity Guaranteed : Produced using recombinant DNA technology, purity ≥ 98%.

Activity confirmation : Cell proliferation assay EC50 < 0.5 nM

Excellent stability : Purity remains above 97% after 6 months of accelerated testing.

✅Global supply assurance :

Cold chain logistics : -20℃ cold chain transportation throughout the entire process to ensure product stability.

Multi-warehouse delivery : Regional warehouses are established in China, Europe, America, and the Asia-Pacific region, ensuring delivery within 7 days.

Customs clearance support : Professional document preparation ensures smooth customs clearance worldwide.

Production process and quality assurance

1. Advanced production technology :

Recombinant technology : Using an E. coli expression system, expression level >500 mg/L

Variant design : Precisely removes amino acids at positions 67-70 while preserving activity.

Purification process : Three-step purification: ion exchange + hydrophobic chromatography + molecular sieve.

2. Strict quality control standards :

Chemical purity :

Main component content: 98.0%~102.0%

Related substances: Single impurity ≤0.1%, total impurities ≤0.5%

Deletion verification: Deletion verification of amino acids at positions 67-70

Biological activity :

Cell proliferation assay: titer not less than 90% of the standard.

Receptor binding assay: Meets quality standards

3. Stability data :

Long-term stability : Stored at -20℃ for 24 months, all indicators meet the requirements.

Accelerated testing : After being stored at 25°C for 6 months, the purity decreased by ≤2.0%.

Stability in use : After reconstitution, store at 2-8℃ for 7 days; purity ≥95%.

Scientific Research Applications and Clinical Prospects

1. Mechanism of action study :

Muscle growth : Promotes the proliferation and differentiation of myoblasts

Tissue repair : Accelerates the repair of tissues such as muscles and cartilage.

Metabolic regulation : regulating glucose and amino acid metabolism

2. Research and application areas :

Sports medicine : Research on muscle damage repair and functional enhancement

Regenerative medicine : Tissue engineering and stem cell therapy research

Metabolic diseases : Studies on diabetes and metabolic syndrome

3. Preclinical data :

Local action : Primarily acts at the injection site; systemic exposure is low.

Enhanced activity : Bioactivity is 10-100 times that of natural IGF-1

Good safety : Variant design reduces the risk of system side effects

The Quality Advantages of Made in China

1. Advantages in manufacturing process :

Expression system : High-density fermentation technology, high expression level

Variant design : Precise amino acid deletion for enhanced activity

Purification process : Three-step chromatography purification, purity ≥98%.

2. Quality Assurance System :

Compliant with standards : Meets Chinese Pharmacopoeia, USP, and EP standards.

Stability study : Complete a comprehensive stability investigation.

Batch consistency : Strict process control ensures consistency between batches.

3. Global supply network :

Production Base : GMP-compliant production base in China

Distribution network : A global distribution and cold chain logistics network

Registration support : Supports registration applications from countries around the world.

Why choose the Chinese-made IGF-1 DES ?

Enhanced Activity : Bioactivity is 10-100 times that of natural IGF-1

Local action : Primarily acts at the injection site, with minimal systemic side effects.

Exceptional purity : Over 98% high purity, with strict quality control.

Stable supply : A complete supply chain ensures timely and reliable delivery.

Summary

Made in China IGF-1 DES 2mg lyophilized powder for injection represents a high-quality standard for growth factor variants . Through advanced recombinant technology, precise variant design, and rigorous quality control , it provides a high-quality, highly active research tool for global muscle growth and tissue repair research . Choosing Made in China means choosing research-grade quality and reliable assurance .

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