Description

Technical Parameters

5 -Amino-1MQ (5-amino-1-methylquinoline) 5mg/bottle Core Introduction

Research -grade lyophilized powder | NNMT enzyme inhibitor (nicotinamide N-methyltransferase inhibitor )

Chemical name : 5-amino-1-methylquinoline

CAS No .: **7151-27-7

Molecular formula : C₁₀H₁₀N₂

Molecular weight : 158.20

Purity : ≥98% (HPLC)

Specifications : 5mg/bottle

Appearance : White to off-white freeze-dried powder

Solvent : 1mL bacteriostatic water

Core Effects

5-Amino-1-methylquinoline (5-Amino-1MQ) is a potent and selective nicotinamide N-methyltransferase (NNMT) inhibitor . Due to its unique metabolic regulation and anti-aging properties , it is widely used in metabolic disease research, anti-aging intervention, and energy metabolism regulation .

✅ NNMT enzyme specific inhibition :

Inhibits nicotinamide N-methyltransferase , blocking the conversion of nicotinamide (NAM) to 1-methylnicotinamide (1-MNAM)

Increase intracellular NAD+ levels and enhance cellular energy metabolism

✅ Metabolic reprogramming effect :

Improve insulin sensitivity and promote glucose metabolism

Reduce fat accumulation and prevent obesity-related metabolic disorders

✅ Anti-aging potential :

Activate sirtuins longevity proteins to delay cell aging

Enhance mitochondrial function and improve age-related metabolic decline

✅ Advantages :

Highly selective and specifically targets NNMT enzyme

High oral bioavailability , easy to administer

End Product Preparation Guidelines

1. Preparation of injection (5 mg/ml) :

Recipe Example (makes 10 bottles):

5-Amino-1MQ raw material: 50mg

Normal saline: add to 10ml

Preparation process :

Raw material dissolution : Dissolve in normal saline, avoid vigorous stirring

pH adjustment : Use dilute hydrochloric acid or sodium hydroxide to adjust the pH to 6.0-7.5

Sterile filtration : 0.22μm membrane positive pressure filtration

Packaging and nitrogen filling : packaging under sterile environment, nitrogen filling protection

Quality Control :

Assay : HPLC method, the content should be 95%-105% of the labeled amount

Related substances : Single impurity ≤ 0.5%, total impurities ≤ 1.0%

Sterility test : in compliance with pharmacopoeia regulations

2. Preparation Notes :

Avoid light operation : sensitive to light, need to operate in dark conditions

Temperature control : low temperature operation throughout the process (2-8℃)

Stability : Use within 4 hours after reconstitution

Usage Protocol

1. Injection method :

Intraperitoneal injection :

Dosage: 1-5 mg/kg once daily

Solvent: physiological saline or PBS buffer

Intravenous injection :

Dosage: 0.5-2 mg/kg once daily

Solvent: Normal saline, slowly push (not less than 5 minutes)

2. Treatment options :

Metabolic disease research :

Obesity model: 2-5 mg/kg/day, intraperitoneal injection, 4-8 weeks

Diabetes model: 1-3 mg/kg/day, intravenous injection, 2-4 weeks

Anti- aging research :

Aging model: 1-2 mg/kg/day, intraperitoneal injection, long-term intervention

The dosage needs to be adjusted according to the specific model

3. Precautions for use :

Use immediately after dissolving , the solution is unstable

Store away from light to prevent degradation

Some animals may experience stress reactions and need to be closely monitored.

Why choose 5-Amino-1MQ ?

The first NNMT enzyme inhibitor , targeting a new pathway for metabolic regulation

Boost NAD+ levels and provide multiple anti-aging benefits

Improving metabolic health , new tools for obesity and diabetes research

Quality Assurance :

GMP -compliant production , each batch HPLC purity tested (≥98% )

Third-party laboratory report (COA) is included with the goods

Microbial limit testing to ensure safety

Worldwide Shipping :

Medical vial packaging , rubber stopper seal

Cold chain transportation (2-8°C) to ensure product stability

Private delivery , no logo on the outer packaging

Conclusion

5-Amino-1MQ is a novel tool compound in metabolic research and anti-aging research . It is particularly suitable for studying NNMT enzyme function, exploring the mechanisms of metabolic diseases, and anti-aging intervention studies . The recommended dose is 1-5 mg/kg/day .

Need anything, please contact us