Description

Technical Parameters

Nolvadex (Tamoxifen) 10mg 100 tablets/bottle Core Information *

Pharmaceutical -Grade Tablets | Tamoxifen Citrate Selective Estrogen Receptor Modulator (SERM )

Chemical Name : (Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine citrate

CAS number : 54965-24-1

Molecular formula : C₂₆H₂₉NO·C₆H₈O₇

Molecular weight : 563.62

Specifications : 10 mg/tablet (as tamoxifen), 100 tablets/bottle

Appearance : White tablet

Core Effects

Tamoxifen (Nolvadex) is a selective estrogen receptor modulator (SERM) widely used for breast cancer treatment, prevention of estrogen-related side effects, and post-steroid cycle recovery (PCT) due to its potent estrogen receptor modulating properties and breast cancer therapeutic applications .

✅ Estrogen receptor regulation :

Competitively binds to estrogen receptors and blocks estrogen signaling

Tissue- selective action , producing agonistic or antagonistic effects in different tissues

✅ Breast cancer treatment application :

Estrogen receptor-positive breast cancer treatment , effectively inhibiting tumor growth

Adjuvant treatment and prevention to reduce the risk of recurrence

✅ Post-Cycle Recovery (PCT) Advantages :

Stimulate endogenous testosterone secretion and quickly restore gonadal function

Prevent estrogen -related side effects

✅ Advantages :

High oral bioavailability and easy to use

Long half-life (5-7 days) and low dosing frequency

Well tolerated and safe for long-term use

End Product Preparation Guidelines

1. Preparation of oral tablets (10 mg/tablet) :

Example recipe (for 1000 tablets):

Tamoxifen citrate raw material: 14.7g (equivalent to 10.0g of tamoxifen)

Microcrystalline cellulose: 80.0g

Lactose: 50.0g

Cross-linked carboxymethyl cellulose sodium: 8.0g

Magnesium stearate: 2.0g

Preparation process :

Raw material pretreatment : micronization (D90≤10μm)

Equal amount incremental mixing : gradually mix with diluent

Wet granulation : granulate with appropriate amount of purified water and dry in fluid bed at 50°C

Granulation : 20 mesh sieve granules, add flow aids and lubricants

Tableting : 6mm round die, 8-10kN pressure tableting

Film coating : Gastro-soluble film coating to improve stability and palatability

Quality Control :

Content uniformity : RSD≤3% (UV-HPLC detection)

Dissolution rate : ≥85% in 30 minutes (paddle method, 50 rpm)

Related substances : Single impurity ≤ 0.5%, total impurities ≤ 1.0%

2. Preparation Notes :

Raw material characteristics : cis (Z-type) isomer is the active ingredient

Production environment : relative humidity ≤ 40%, avoid light operation

Packaging requirements : Aluminum foil blister packaging, light-proof and moisture-proof

Cycle Protocol

1. Breast cancer treatment :

Dosage : 20-40 mg/day, taken orally in 1-2 divided doses

Treatment duration : Long-term treatment (5-10 years)

Monitoring : Regular gynecological examinations and bone density testing

2. Post-Cycle Recovery (PCT) :

Dosage : 20 mg/day, single oral dose

Duration : 4-6 weeks

Effect : Rapid recovery of endogenous testosterone levels

3. Prevention of estrogen side effects :

Dosage : 10-20 mg/day, single oral dose

Cycle : Used in conjunction with a steroid cycle

Effect : Effectively prevents estrogen-induced milk production and water retention

4. Dosage adjustment guidelines :

Starting dose : 10 mg/day to test tolerance

Therapeutic dose : 20-40 mg/day (breast cancer treatment)

Preventive dose : 10-20 mg/day (for side effect prevention)

Maximum dose : no more than 40 mg/day

Lifecycle Support and Management

Support in use :

Gynecological monitoring :

Regular gynecological examinations to prevent endometrial hyperplasia

Bone density monitoring to prevent osteoporosis

Liver function protection :

Silymarin 600 mg/day

N-acetylcysteine 1200 mg/day

Side Effect Management :

Hot flashes : Vitamin E 400 IU/day

Endometrial hyperplasia : Regular ultrasound examinations

Thrombotic risk : Aspirin 100 mg/day (high-risk group)

Why choose tamoxifen ?

One of the most classic SERMs with a good clinical safety record

Dual function benefits , can be used for breast cancer treatment and cycle recovery

Easy to use , less painful to take orally

Quality Assurance :

GMP compliant production , content uniformity testing for each batch

Third-party laboratory report (COA) is included with the product

Aluminum foil blister packaging to ensure stability

Worldwide Shipping :

100 tablets/bottle economical pack to meet treatment needs

Original sealed packaging , private delivery

Temperature -controlled transportation to ensure drug efficacy

Conclusion

Tamoxifen is an ideal choice for breast cancer treatment and cycle recovery , especially for the treatment of estrogen receptor-positive breast cancer, recovery after steroid cycles, and prevention of estrogen side effects . The recommended dose is 10-40mg/day .

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