Description

Technical Parameters

LGD-3303 99% Raw Material Powder Core Introduction

Pharmaceutical-grade raw material | Made in China LGD-3303 (Highly selective androgen receptor modulator)

Chemical name : 4-(2-(2,2,2-trifluoroethoxy)phenyl)-2-(trifluoromethyl)benzofuran-7-carboxamide

CAS No .: 1140908-14-1

Molecular formula : C₁₈H₁₁F₆NO₃

Molecular weight : 403.28

EINECS ID : Pending Assignment

Melting point : 192-195℃

Appearance : White crystalline powder

Purity : ≥99% (HPLC detection)

Solubility : Easily soluble in DMSO, slightly soluble in ethanol

Core Function | Core Effects

LGD-3303 is a highly selective androgen receptor modulator (SARM) that is widely used for the treatment of muscle atrophy, osteoporosis research and selective androgen regulation due to its unique trifluoromethylbenzofuran structure and tissue selectivity .

✅High selectivity mechanism :

Tissue selectivity : High agonistic activity is observed in skeletal muscle and bone tissue.

Receptor affinity : High affinity for androgen receptors, EC50 < 1 nM

Partial agonist properties : These properties reduce the risk of side effects.

✅Quality advantages of Chinese manufacturing :

Ultra-high purity : Raw material purity ≥ 99%, single impurities ≤ 0.1%

Crystal form control : Stable α-crystal form ensures formulation reproducibility.

Chiral purity : Optical purity of chiral centers ≥ 99.8%

✅Global supply assurance :

Cold chain logistics : constant temperature transportation at 15-25℃ to ensure stability.

Multiple packaging options : 1kg/bag, 5kg/drum, and more.

Customs clearance support : Complete export documents such as MSDS and COA

Production process and quality assurance

1. Advantages of the synthesis process :

Chiral synthesis : Asymmetric synthesis techniques ensure correct chiral center configuration.

Purification process : Column chromatography combined with recrystallization to obtain high-purity crystals.

Drying technology : Vacuum low-temperature drying, moisture content ≤0.5%

2. Strict quality control standards :

Chemical purity :

Main component content: 99.0%~101.0%

Related substances: Single unknown impurity ≤ 0.1%, total impurities ≤ 0.5%

Residual solvent: Complies with ICH Q3C standards

Physical properties :

Particle size distribution: D50 50-100μm

Bulk density: 0.4-0.6 g/cm³

Solubility: Meets the standards for active pharmaceutical ingredients.

3. Stability data :

Long-term stability : Stable for 36 months at 25℃/60%RH.

Accelerated testing : Passed after 6 months at 40℃/75%RH.

Transportation stability : Vibration and drop tests passed.

Scientific Research Applications and Clinical Prospects

1. Research and application areas :

Treatment for muscle atrophy : cancer cachexia, age-related sarcopenia

Osteoporosis : Increases bone density and improves bone quality

Selective androgen regulation : Tissue-selective androgen action

2. Preclinical data :

Significant efficacy : Animal studies show a 10-15% increase in lean body mass.

Skeletal Improvement : Significantly increased bone mineral density and improved bone biomechanical properties

High selectivity : minimal impact on the prostate, significant tissue selectivity.

3. Key Features and Advantages :

Effective orally : High oral bioavailability, suitable for long-term administration.

Wide therapeutic window : Wide safe dosage range, low risk of side effects

Metabolic stability : Good metabolic stability in the body, with a moderate half-life.

Global supply and service assurance

1. Production capacity :

Annual production capacity : Over 100 kg per year

Flexible manufacturing : Customized specifications and packaging requirements are acceptable.

Production capacity assurance : Multiple production lines ensure stable supply

2. Quality Certification :

System Certification : Certified by ISO 9001 Quality Management System

Compliance with standards : Meets pharmaceutical raw material standards

Complete documentation : Provides a complete package of quality documentation.

3. Logistics support :

Professional Packaging : Triple protection with aluminum foil bag + desiccant + vacuum packaging

Real-time monitoring : Equipped with a temperature and humidity recorder, allowing for full traceability.

Emergency Plan : Establish an emergency response mechanism for abnormal situations.

Why choose the Chinese-made LGD-3303?

High selectivity : Tissue-selective androgen regulation with low risk of side effects

Exceptional purity : Over 99% high purity, with strict impurity control.

Advanced technology : Chiral synthesis technique, optical purity up to 99.8%

Reliable supply : Large-scale production capacity, timely delivery

Summarize

Made in China, LGD-3303 99% raw material powder represents the high-quality standard of highly selective androgen receptor modulators . Through advanced chiral synthesis technology, rigorous quality control, and a stable supply system , it provides high-quality, highly active research raw materials for global research on muscle atrophy and osteoporosis . Choosing Made in China means choosing professional quality and reliable assurance .

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