Description

Technical Parameters

Toremifene Citrate (toremifene citrate) raw material powder core introduction

Pharmaceutical Grade Ingredients | Toremifene Citrate, a Selective Estrogen Receptor Modulator (SERM )

Chemical name : (Z)-2-{4-[(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine citrate

CAS number : 89778-27-8

Molecular formula : C₂₆H₂₈ClNO·C₆H₈O₇

Molecular weight : 598.09

Melting point : 108-110°C

Appearance : White or off-white crystalline powder

Purity : ≥98% (HPLC)

Core Effects

Toremifene citrate is a selective estrogen receptor modulator (SERM) that is widely used for breast cancer treatment, prevention of estrogen-related side effects, and post-steroid cycle recovery (PCT) due to its potent estrogen receptor modulating properties and good tolerability .

✅ Potent estrogen receptor regulation :

Competitively binds to estrogen receptors and blocks estrogen signaling

Tissue- selective effects , producing agonistic or antagonistic effects on different tissues

✅ Breast cancer treatment application :

Estrogen receptor-positive breast cancer treatment , effectively inhibiting tumor growth

Well tolerated and safe for long-term use

✅ Post-Cycle Recovery (PCT) Advantages :

Stimulate endogenous testosterone secretion and quickly restore gonadal function

Prevent estrogen -related side effects

✅ Advantages :

Long half-life (5-7 days) and low dosing frequency

Low hepatotoxicity and safer than tamoxifen

Multiple application values , can be used in medical and sports fields

End Product Preparation Guidelines

1. Oral tablet preparation (60 mg/tablet) :

Example recipe (for 1000 tablets):

Toremifene citrate raw material: 60.0g (calculated as toremifene)

Microcrystalline cellulose: 80.0g

Lactose: 50.0g

Cross-linked carboxymethyl cellulose sodium: 8.0g

Magnesium stearate: 2.0g

Preparation process :

Raw material pretreatment : micronization (D90≤10μm)

Equal amount incremental mixing : gradually mix with diluent

Wet granulation : granulate with appropriate amount of purified water and dry in fluid bed at 50°C

Granulation : 20 mesh sieve granules, add flow aids and lubricants

Tableting : 8mm round die, 8-10kN pressure tableting

Film coating : Gastro-soluble film coating to improve stability and palatability

Quality Control :

Content uniformity : RSD≤3% (UV-HPLC detection)

Dissolution rate : ≥85% in 30 minutes (paddle method, 50 rpm)

Related substances : Single impurity ≤ 0.5%, total impurities ≤ 1.0%

2. Preparation Notes :

Raw material characteristics : Triphenylethylene derivative, highly photosensitivity

Production environment : relative humidity ≤ 40%, avoid light operation

Packaging requirements : Aluminum foil blister packaging, light-proof and moisture-proof

Why choose toremifene ?

One of the safest SERMs with extremely low risk of hepatotoxicity

Long half-life , reducing dosing frequency and improving convenience

Dual function benefits , can be used for breast cancer treatment and cycle recovery

Quality Assurance :

GMP -compliant production , each batch HPLC purity tested (≥98% )

Third-party laboratory report (COA) is included with the goods

Microbial limit testing to ensure safety

Worldwide Shipping :

Original sealed packaging , moisture-proof and light-proof

Private delivery , no logo on the outer packaging

Temperature -controlled transportation to ensure stability

Conclusion

Toremifene citrate can be formulated into an oral dosage form using a standard tableting process . It is particularly suitable for breast cancer treatment, prevention of estrogen-related side effects, and recovery after steroid cycles . The recommended dose is 60mg/day .

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