Description

Technical Parameters

Progesterone Raw Material Powder Core Introduction

Pharmaceutical Grade Ingredients | Progesterone (Natural Progestogen )

Chemical Name : Pregnane-4-ene-3,20-dione

CAS number : 57-83-0

EINECS number : 200-350-6

Molecular formula : C₂₁H₃₀O₂

Molecular weight : 314.46

Melting point : 128-131°C

Specific rotation : +172° to +182° (c=1, dioxane)

Appearance : White or off-white crystalline powder

Solubility : Very slightly soluble in water, easily soluble in ethanol, acetone, soluble in vegetable oil

Core Properties

Progesterone is a natural progestogen . As the main active hormone secreted by the corpus luteum , it plays a key role in menstrual cycle regulation, pregnancy maintenance, and embryonic development . It is widely used in the treatment of gynecological diseases and assisted reproductive technology .

✅ Comprehensive physiological functions :

Endometrial transformation : promoting changes in the endometrium during the secretory phase

Pregnancy maintenance : Reduce uterine excitability and maintain pregnancy

Breast development : Promotes the development of mammary gland alveoli and prepares for breastfeeding

✅ Unique pharmacological effects :

Receptor selectivity : Highly selective binding to progesterone receptors

Hormone balance regulation : counteracting estrogen overstimulation

Neuroprotective effects : Has neurosteroid activity and improves sleep

✅ Significant therapeutic value :

Threatened Abortion : Effective Prevention and Treatment of Habitual Abortion

Irregular menstruation : regulate menstrual cycle and treat dysfunctional uterine bleeding

Assisted reproduction : Luteal support to improve pregnancy success rate

Potential end products and applications

1. Oral capsule (100mg/200mg) :

Micronization technology :

Raw materials are micronized, particle size D90≤10μm

Increase bioavailability to 6-10% (common preparations are only <2%)

Capsule formula (100mg softgel):

Progesterone raw material: 100mg

Medium chain triglycerides: 400mg

Soy lecithin: 20mg

Vitamin E: 2mg (antioxidant)

Process features :

Low temperature filling to prevent raw material degradation

Light-proof packaging to ensure stability

Enteric-coated capsules are available to reduce gastrointestinal reactions

2. Vaginal preparations :

Various dosage forms :

Vaginal suppository : 100mg/pill, use before bed

Vaginal gel : 8% (90 mg/dose), 1-2 times daily

Vaginal tablet : 100 mg, slow-release

Local advantages :

First -pass effect : Direct action on the endometrium

Stable blood drug concentration : avoid peak and valley fluctuations, and minimize side effects

Easy to use : High patient acceptance

3. Oil for injection (50mg/ml) :

Formula composition :

Progesterone raw material: 50mg

Tea oil: 1ml (oil for injection)

Benzyl alcohol: 2% (preservative)

Preparation process :

Sterile filtration, nitrogen protection

Ampoules are sealed to avoid oxidation

Autoclave to ensure sterility

Clinical Applications :

Urgent need for rapid onset of action

Patients who cannot take medication orally or vaginally

Luteal support in assisted reproductive cycles

4. Transdermal gel (8%) :

Formulation technology :

Progesterone raw material: 8g

Carbomer: 1.2g (gel matrix)

Ethanol: 40g (permeation enhancer)

Propylene glycol: 10g (humectant)

Triethanolamine: appropriate amount (pH adjustment)

Features :

Apply to arms, abdomen, thighs, etc.

1-2 times daily, avoiding the breast area

Stable blood drug concentration and easy to use

Usage Protocol

1. Treatment of luteal phase insufficiency :

Medication regimen :

Oral administration : 200-300 mg/day, divided into two doses

Vaginal administration : 90 mg twice daily

Injection : 50 mg/day, intramuscular injection

When to take the medicine :

Start taking the medicine after ovulation and use it continuously for 10-14 days

If pregnant, continue to take the medicine until 10-12 weeks of pregnancy

Gradually reduce the dosage to avoid a sudden drop in hormone levels

2. Luteal support for assisted reproductive technology :

Personalized plan :

IVF cycle : Medication starts after egg retrieval

Frozen embryo transfer : Start taking medication 3-5 days before transfer

Dosage : Adjusted according to endometrial condition and hormone levels

Monitoring indicators :

serum progesterone level

Endometrial thickness and morphology

Early pregnancy indicators (HCG, estradiol)

3. Perimenopause hormone therapy :

Combination drug regimen :

Sequential estrogen-progestin therapy: mimicking the menstrual cycle

Continuous combination regimen: daily fixed dose

Cyclic medication: 10-14 days per month

Dosage adjustments :

Individualized adjustment based on symptom severity

Regular evaluation of efficacy and safety

Minimum effective dose principle

Use of special dosage forms

1. Instructions for use of vaginal preparations :

Correct usage :

Use before bed to keep the drug longer

Avoid immediate activity after use and lie flat for 30 minutes

Place deeply to ensure that the drug fully contacts the cervix

Notes :

A small amount of secretion may occur, which is normal

Avoid use during menstruation

If you forget to take your medicine, take it as soon as you remember

2. Instructions for use of transdermal gel :

Applying tips :

Rotate the application area to avoid local irritation

Allow to dry completely before getting dressed

Use after bathing for better absorption

Dosage Control :

Use a metering pump to accurately dispense

Apply evenly to an area of about 20×20cm

Massage until fully absorbed

Why choose progesterone raw materials ?

Physiological matching : consistent with the structure of endogenous progesterone, high safety

Multiple dosage forms : Suitable for developing oral, vaginal, injectable and other dosage forms

Wide clinical application : gynecology, reproduction, perinatal and other fields

Mature technology : Stable formulation technology and controllable quality

Conclusion

Progesterone raw materials are the core raw material for the preparation of progestogen-based drugs . Through different formulation technologies, they can be manufactured into a variety of end products, including oral micronized capsules, vaginal preparations, injectables, and transdermal formulations . Choosing us will provide you with high-purity raw materials, professional technical support, and comprehensive after-sales service .

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