Description

Technical Parameters

Procaine HCl (procaine hydrochloride) raw material powder core introduction

Pharmaceutical Grade Ingredients | Procaine Hydrochloride (Base Material for Local Anesthetics )

Chemical name : 2-(Diethylamino)ethyl 4-aminobenzoate hydrochloride

CAS number : 51-05-8

EINECS number : 200-092-1

Molecular formula : C₁₃H₂₁ClN₂O₂

Molecular weight : 272.77

Melting point : 153-156°C

Appearance : White crystalline powder

Solubility : easily soluble in water, slightly soluble in ethanol

Core Properties

Procaine hydrochloride is a short-acting ester local anesthetic raw material . Due to its rapid onset of action and good safety profile , it is widely used in pharmaceutical preparations, cosmetics, and veterinary medicine .

✅ Pharmacological properties :

Fast onset : Anesthetic effect occurs within 1-3 minutes after injection

Short duration : The anesthetic effect lasts for 45-60 minutes

Strong diffusivity : Good tissue penetration and diffusivity

✅ Safety Features :

Rapid metabolism : Rapidly hydrolyzed by esterases in plasma

Low toxicity : wide therapeutic index and large safety margin

Fewer allergic reactions : The allergy rate is lower than other ester anesthetics

Possible end products and applications

1. Injectable anesthetics :

Formulation :

Procaine hydrochloride: 2%

Sodium chloride: 0.9%

Water for injection: up to 100%

Clinical Applications :

Infiltration anesthesia : 0.25%-0.5% solution for local infiltration

Nerve block : 1%-2% solution for regional nerve blocks

Spinal anesthesia : 10% hypertonic solution for subarachnoid block

2. Dental anesthetics :

Formulation :

Procaine hydrochloride: 2%-4%

Epinephrine: 1:50,000-1:200,000

Preservatives: 0.1%

Clinical Applications :

Dental treatment : used for dental procedures such as tooth extraction and root canal treatment

Mucosal anesthesia : used for surface anesthesia of the oral mucosa

3. Topical anesthetic preparations :

Formulation :

Procaine hydrochloride: 5%-10%

Base: Cream, gel or ointment base

Penetration enhancer: Azone, etc.

Clinical Applications :

Skin surface anesthesia : used for small wound suture, laser beauty, etc.

Mucosal anesthesia : used for anesthesia of mucous membranes such as urethra and rectum

4. Compound analgesic injection :

Common combination :

Procaine + Penicillin : Reducing the pain of penicillin injection

Procaine + Vitamin B12 : For the treatment of neuropathic pain

Procaine + cortisol : for the treatment of inflammatory pain

Usage Protocol

1. Dosage control :

Maximum single dose for adults : no more than 1g

Concentration selection :

Infiltration anesthesia: 0.25%-0.5%

Nerve block: 1%-2%

Spinal anesthesia: 10%

2. Usage :

Preparation before injection :

Check solution clarity

Confirm that there is no crystal precipitation

Skin allergy test (if necessary)

Injection technique :

Inject slowly, paying attention to withdrawing to avoid intravascular injection

Inject in several times and observe the patient's reaction

Strictly control the injection speed

3. Use in special populations :

Children's medication :

The dosage is calculated based on body weight, usually 1/2-2/3 of the adult dosage

Strictly monitor dosage to avoid overdose

Medication for the elderly :

Decreased liver and kidney function, appropriate reduction of dosage

Extend the dosing interval

4. Adverse reaction management :

Common side effects :

Central nervous system: dizziness, drowsiness, tremors

Cardiovascular system: changes in heart rate, decrease in blood pressure

Allergic reaction: rash, difficulty breathing

Handling measures :

Stop taking the drug immediately

Maintain airway patency

Antihistamines if necessary

Why choose procaine raw material ?

Cost-effectiveness : Lower cost compared to other local anesthetics

High safety : fewer allergic reactions and a wide therapeutic index

Widely used : Can be used in a variety of dosage forms

Good stability : The raw materials are easy to store and transport

Conclusion

Procaine hydrochloride is an important base material for the preparation of various local anesthetics . Through different formulation processes , it can be manufactured into a variety of end products, including injections, topical preparations, and compound preparations . Choosing us will provide you with high-purity raw materials, professional technical support, and comprehensive after-sales service .

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