Description

Technical Parameters

Exemestane (exemestane) raw material powder core introduction

Pharmaceutical -grade raw materials | Exemestane aromatase inhibitor

Chemical Name : 6-Methyleneandrost-1,4-diene-3,17-dione

CAS number : 107868-30-4

Molecular formula : C₂₀H₂₄O₂

Molecular weight : 296.41

Melting point : 191-194°C

Appearance : White or off-white crystalline powder

Purity : ≥98% (HPLC)

Core Effects

Exemestane is an irreversible aromatase inhibitor . Due to its potent estrogen-suppressing properties and unique drug mechanism , it is widely used in the treatment of breast cancer, prevention of estrogen-related side effects, and estrogen control during steroid cycles .

✅ Potent estrogen suppression :

Irreversibly binds to aromatase , permanently inactivating enzyme activity

Reduce estradiol levels and effectively control estrogen-related side effects

✅ Unique drug mechanism :

Steroid backbone structure , competitive binding to aromatase substrate

Suicide inhibition , permanent inactivation of aromatase

✅ Estrogen control during the cycle :

Preventing female breasts and male breast development

Reduce water retention , maintain muscle firmness and definition

✅ Breast cancer treatment application :

Treatment of postmenopausal breast cancer , effectively inhibiting tumor growth

Well tolerated and safe for long-term use

End Product Preparation Guidelines

1. Oral tablet preparation (25 mg/tablet) :

Example recipe (for 1000 tablets):

Exemestane raw material: 25.0g

Microcrystalline cellulose: 80.0g

Lactose: 50.0g

Cross-linked carboxymethyl cellulose sodium: 8.0g

Magnesium stearate: 2.0g

Preparation process :

Raw material pretreatment : micronization (D90≤10μm)

Equal amount incremental mixing : gradually mix with diluent

Wet granulation : granulate with appropriate amount of purified water and dry in fluid bed at 50°C

Granulation : 20 mesh sieve granules, add flow aids and lubricants

Tableting : 6mm round die, 8-10kN pressure tableting

Film coating : Gastro-soluble film coating to improve stability and palatability

Quality Control :

Content uniformity : RSD≤3% (UV-HPLC detection)

Dissolution rate : ≥85% in 30 minutes (paddle method, 50 rpm)

Related substances : Single impurity ≤ 0.5%, total impurities ≤ 1.0%

2. Preparation Notes :

Raw material characteristics : steroid skeleton structure, high fat solubility

Production environment : relative humidity ≤ 40%, moisture-proof treatment

Packaging requirements : Aluminum foil blister packaging, light-proof and moisture-proof

Why choose exemestane ?

One of the most potent aromatase inhibitors , with reliable results

Irreversible inhibition mechanism , long-lasting efficacy

Multiple application values , can be used in medical and sports fields

Quality Assurance :

GMP -compliant production , each batch HPLC purity tested (≥98% )

Third-party laboratory report (COA) is included with the goods

Microbial limit testing to ensure safety

Worldwide Shipping :

Original sealed packaging , moisture-proof and light-proof

Private delivery , no logo on the outer packaging

Temperature -controlled transportation to ensure stability

Conclusion

Exemestane can be manufactured into an oral dosage form using a standard tableting process . It is particularly suitable for breast cancer treatment, prevention of estrogen-related side effects, and estrogen control during steroid cycles . The recommended dose is 25mg/day .

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