Cartalax 20mg/vial Health Maintenance Of Joints And Cartilage Tissue

Cartalax 20mg/bottle core introduction

Pharmaceutical-grade peptide formulations | Made in China joint cartilage repair peptides 20mg/vial

Specifications : 20mg/bottle, 5 bottles/box

Purity : ≥99% (HPLC detection)

Appearance : White to off-white lyophilized powder

Storage : Refrigerate at 2-8℃, protected from light. After rehydration, store in the refrigerator.

Core advantages and functions

Cartalax is a synthetic polypeptide that targets articular cartilage repair . By specifically regulating chondrocyte metabolism and extracellular matrix homeostasis , it shows significant application potential in the treatment of osteoarthritis, joint injury repair, and sports medicine , and is a key bioactive tool for orthopedic and regenerative medicine research .

✅Cartilage repair mechanism :

Cell proliferation promotion : Enhances the proliferative activity of chondrocytes and mesenchymal stem cells.

Regulation of matrix synthesis : Upregulation of expression of key matrix components such as type II collagen and proteoglycans

Inflammation suppression : Downregulation of inflammatory and catabolic mediators such as IL-1β, TNF-α, and MMPs

Cell protection : Reduces oxidative stress and apoptosis, and maintains chondrocyte homeostasis.

✅Quality advantages of Chinese manufacturers :

Design and Synthesis : Rational Peptide Design Based on Structure-Function Relationships, Fmoc Solid-Phase Synthesis

Purification process : Preparative HPLC combined with ion exchange chromatography ensures the main component content is ≥99%.

Activity validation : In vitro chondrocyte/tissue model validation, EC50 ≤ 10 nM

Aseptic protection : Grade C clean environment, automated filling and freeze-drying line

Quality control system : Full batch COA, including HPLC, MS, and amino acid composition analysis.

✅Product Features :

Targeted cartilage : has a natural affinity for articular cartilage tissue

Excellent stability : The optimized freeze-drying formulation exhibits good long-term stability.

High safety profile : Preclinical toxicology studies show a wide therapeutic window.

Synergistic effect : Can be used in combination with hyaluronic acid, PRP, stem cells, etc.

Usage and Storage Guide

1. Reconstitution and preparation :

Solvent selection :

First choice: Sterile saline

For research purposes: Serum-free chondrocyte culture medium (for in vitro experiments)

Special: Sodium hyaluronate solution (1-2%, for intra-articular compounding)

Standard preparation : Inject 2 mL of solvent into a 20 mg vial to obtain a 10 mg/mL stock solution .

Dissolving procedure : Dissolve gently by rotating at room temperature ; do not shake or sonicate.

Preparation of working solution :

In vitro cell experiments: Dilute with culture medium to 1-50 µg/mL

Animal in vivo experiments: Dilute with physiological saline to the required concentration

Material loading: Blended with scaffold material solution

2. Storage conditions :

Unreconstituted : Stable for 24 months when refrigerated at 2-8℃ ; shelf life can be extended at -20℃.

Reconstituted stock solution : Stable for 7 days when refrigerated at 2-8℃.

Working solution : It is recommended to prepare it fresh before use and store it at 4°C for no more than 24 hours.

Transportation : Cold chain throughout (2-8℃), using professional temperature-controlled packaging.

Note : Keep away from light and avoid repeated freeze-thaw cycles (≤3 times).

3. Study the dosing regimen :

In vitro cell experiments :

Concentrations: 1, 10, 50 µg/mL

Processing time: 24, 48, 72 hours

Replacement frequency: Replace with fresh culture medium containing the drug every 24-48 hours.

Animal in vivo studies :

Intra-articular injection (preferred):

Dosage: 1-2 mg per joint (rat/rabbit knee joint)

Volume: 50-100 µL

Frequency: 1-2 times per week

Treatment course: 4-8 weeks

Subcutaneous injection (systemic effects):

Dosage: 0.5-2 mg/kg body weight

Frequency: Once daily or every other day

Tissue engineering applications :

Stent loading concentration: 0.1-1.0 mg/mL Stent material

Loading methods: physical adsorption, blending, chemical coupling

Release cycle: Designed for 1-4 weeks of sustained release.

4. Experimental Design Suggestions :

Model of osteoarthritis (OA) :

ACLT (Anterior Cruciate Ligament Transsection) Model

MIA (sodium iodoacetate) induced model

Dosage: Intra-articular injection, 1 mg/time, twice a week for 4 weeks.

Assessment: Histology (OARSI score), micro-CT, behavioral studies

Cartilage defect model :

Full-thickness cartilage defect (2-3 mm in diameter)

Dosage: Loaded onto the stent, 0.5 mg/cm³ defect

Assessment: Histological and biomechanical findings at 12 weeks

Combined treatment study :

Combined with mesenchymal stem cells

Combined with platelet-rich plasma

Combined with low-intensity pulsed ultrasound

Control group setup :

Blank control (solvent)

Positive control (e.g., TGF-β1, 10 ng/mL)

Negative control (irrelevant sequence peptide)

Why choose Cartalax, made in China?

Innovation and Quality : Self-designed active sequences, strict GMP-like production standards

High cost-performance ratio : Compared to imported research peptides of the same type, the price advantage is 40-60%.

Professional Service : Providing detailed technical documents, references, and consultation on experimental plans.

Supply Guarantee : Large-scale production capacity ensures timely delivery.

Customization capabilities : We can provide derivatization services such as fluorescent labeling and biotin labeling.

Research and application directions

Basic mechanism research :

Chondrocyte metabolism and signal transduction pathways

Extracellular matrix synthesis and degradation balance

Molecular mechanisms of mechanical stress and cellular response

Disease model research :

Disease-modifying treatment strategies for osteoarthritis

Early intervention for post-traumatic osteoarthritis

Cartilage protection in rheumatoid arthritis

Regenerative medicine :

Construction and functionalization of tissue-engineered cartilage

Induction and regulation of stem cell differentiation into chondrocytes

Integrated osteochondrogenic repair strategy

Translational and Preclinical :

Development of novel intra-articular drug delivery formulations

Functional optimization of joint repair biomaterials

Evaluation of the synergistic effect of combination therapy

Summarize

Cartalax represents China's technological strength in the research and development of orthopedic bioactive peptides . We have established a complete and controllable R&D and production system, from sequence design and synthesis purification to activity verification . This product provides researchers worldwide with a highly active, specific, and stable research tool for osteoarthritis , and is expected to promote basic research and translational applications in the field of cartilage repair.

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