Description

Technical Parameters

AICAR 50mg/bottle core introduction

Pharmaceutical-grade peptide formulation | AICAR (5-aminoimidazole-4-formamide ribonucleoside ) , made in China

Chemical name : 5-aminoimidazolium-4-carboxamide ribonucleoside

CAS No .: 2627-69-2

Specification : 50mg/bottle

Dosage form : Lyophilized powder for injection

Molecular formula : C₉H₁₄N₄O₅

Molecular weight : 258.23

Melting point : 214-216℃

Appearance : White freeze-dried lumpy powder

Purity : ≥98% (HPLC detection)

Storage conditions : Store at -20℃ away from light.

Core Effects

AICAR is an AMP-activated protein kinase (AMPK) agonist that is widely used in research on metabolic diseases, exercise endurance improvement, and ischemia-reperfusion injury protection due to its unique adenosine analog structure and energy metabolism regulation properties .

✅Energy metabolism regulation mechanism :

AMPK activation : mimicking AMP molecules to activate the AMPK signaling pathway.

Glucose uptake : Promotes glucose transporter 4 (GLUT4) translocation

Fatty acid oxidation : Enhances fatty acid β-oxidation and reduces fat accumulation.

✅Quality advantages of Chinese manufacturing :

Purity Guaranteed : Chemically synthesized, purity ≥ 98%, single impurities ≤ 0.1%.

Chiral purity : Optical purity of the chiral ribose center ≥ 99.8%

Excellent stability : Purity remains above 97% after 6 months of accelerated testing.

✅Global supply assurance :

Cold chain logistics : -20℃ cold chain transportation throughout the entire process to ensure product stability.

Multi-warehouse delivery : Regional warehouses are established in China, Europe, America, and the Asia-Pacific region, ensuring delivery within 7 days.

Customs clearance support : Professional document preparation ensures smooth customs clearance worldwide.

Production process and quality assurance

1. Advanced synthesis process :

Chemical synthesis : A protecting group strategy was employed, achieving a condensation efficiency >99.5%.

Purification process : Preparative HPLC purification, gradient elution, collection of the main peak.

Freeze-drying technology : temperature-controlled freeze-drying, moisture content ≤3.0%.

2. Strict quality control standards :

Chemical purity :

Main component content: 98.0%~102.0%

Related substances: Single impurity ≤0.1%, total impurities ≤0.5%

Residual solvent: Complies with ICH Q3C standards

Biological activity :

AMPK activation test: potency not less than 90% of the standard.

Glucose uptake test: Meets quality standards

3. Stability data :

Long-term stability : Stored at -20℃ for 24 months, all indicators meet the requirements.

Accelerated testing : After being stored at 25°C for 6 months, the purity decreased by ≤2.0%.

Stability in use : After reconstitution, store at 2-8℃ for 7 days; purity ≥95%.

Scientific Research Applications and Clinical Prospects

1. Mechanism of action study :

Energy metabolism : regulating cellular energy status through the AMPK pathway

Mitochondrial biosynthesis : promoting mitochondrial generation and improving function

Insulin sensitivity : Enhances insulin sensitivity and improves glucose metabolism.

2. Research and application areas :

Metabolic diseases : Research on the mechanisms of type 2 diabetes and obesity

Sports Medicine : Research on Exercise Endurance Improvement and Fatigue Recovery

Cardiovascular protection : A study on the protective mechanism of myocardial ischemia preconditioning

3. Preclinical data :

Endurance Improvement : Animal studies show an increase of 30-40% in exercise endurance.

Metabolic improvement : Improves insulin sensitivity and glucose and lipid metabolism

Good safety profile : wide therapeutic window, low risk of side effects.

China's manufacturing quality advantages

1. Advantages in manufacturing process :

Synthesis technology : multi-step chemical synthesis with high overall yield

Purification process : Preparative HPLC purification, purity ≥ 98%.

Quality control : Quality control throughout the entire process from raw materials to finished products.

2. Quality Assurance System :

Compliant with standards : Meets Chinese Pharmacopoeia, USP, and EP standards.

Stability Study : Complete a comprehensive stability investigation.

Batch consistency : Strict process control ensures consistency between batches.

3. Global supply network :

Production Base : GMP-compliant production base in China

Distribution network : A global distribution and cold chain logistics network

Registration support : Supports registration applications from countries around the world.

Why choose AICAR manufactured in China ?

Innovative Mechanism : The first AMPK-target agonist with a unique mechanism

Precise chirality : Optical purity of ribose chiral centers ≥99.8%

Exceptional purity : Over 98% high purity, with strict quality control.

Stable supply : A complete supply chain ensures timely and reliable delivery.

Summary

AICAR 50mg lyophilized powder for injection, made in China, represents a high-quality standard for energy metabolism regulators . Through advanced synthesis processes, rigorous quality control, and a stable supply system , it provides high-quality, highly active research tools for global metabolic disease and sports medicine research . Choosing "Made in China" means choosing research-grade quality and reliable assurance .

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