5-amino-1mq 5mg/vial Supporting Cellular Energy Metabolism And Healthy Aging

5-Amino-1MQ 5mg/bottle core introduction

Research-grade potent NNMT inhibitor | Made in China nicotinamide N-methyltransferase inhibitor 5mg/vial

Generic name : 5-amino-1-methylquinolinium

Chemical name : 5-amino-1-methylquinolinium

English name : 5-Amino-1-methylquinolinium

CAS No .: 66276-61-7

Chemical formula : C₁₀H₁₁N₂⁺

Molecular weight : 159.21 g/mol

Appearance : White to off-white crystalline powder

Purity : ≥98.5% (HPLC)

Storage : Refrigerate at 2-8℃, away from light and stored in a dry place.

Usage and Storage Guide

1. Reconstitution and preparation :

Recommended solvent :

Preferred solvent : Dimethyl sulfoxide (DMSO) . This product has good solubility in DMSO and can be prepared into high-concentration stock solutions (e.g., 50-100 mM).

Aqueous solvents : Since 5-amino-1MQ is usually present in the form of salts (such as iodide, toluenesulfonate), it also has some solubility in sterile deionized water or phosphate-buffered saline (PBS) , but may require slight heating (such as a 37°C water bath) and brief vortexing to aid dissolution.

Precautions : DMSO is hygroscopic and must be sealed after opening. High concentrations of DMSO are toxic to cells; the recommended final working concentration for in vitro cell experiments is no more than 0.1% (v/v) of DMSO .

Standard preparation process :

Calculate the required stock solution concentration. For example, to prepare a 50 mM (50 mmol/L) stock solution:

The molecular weight is 159.21 g/mol.

Weigh or take 5 mg of this product; its amount of substance is approximately 5 mg / 159.21 mg/mmol ≈ 0.0314 mmol.

To obtain a concentration of 50 mM, the required solvent volume is 0.0314 mmol / 0.050 mol/L = 0.628 mL.

Therefore, adding approximately 0.63 mL of DMSO to a 5 mg sample yields a stock solution of approximately 50 mM.

After adding the calculated solvent, gently vortex or let stand at room temperature for several minutes until the powder is completely dissolved and a clear solution is formed.

Dilute the stock solution to the working concentration using the appropriate cell culture medium or buffer (ensuring that the DMSO is adequately diluted) as required by the experiment.

Working concentration reference :

In vitro cell experiments : The commonly used working concentration range is 1 μM to 100 μM . The specific concentration needs to be optimized according to cell type, exposure time, and research objectives (such as IC50 determination). Dose-dependent experiments are recommended.

In vivo animal studies : Dosage needs to be determined based on the animal model, route of administration (intraperitoneal injection, oral gavage, etc.), and experimental design. Doses in mouse models reported in the literature can be used as a reference, but must be validated independently .

Key points to note :

The preparation process should be carried out in a clean environment to avoid microbial contamination.

aliquot the stock solution into smaller portions (e.g., 10-20 μL/tube) and store them at -20°C or -80°C to avoid repeated freeze-thaw cycles.

Before use, take out the required amount from the refrigerator, thaw at room temperature or in a cold water bath, and briefly centrifuge to concentrate the liquid at the bottom of the tube before opening the cap for use.

2. Storage conditions :

Unprepared raw material powder :

For short-term use (within a few months): Store at 2-8℃ in a cool, dark, and dry place .

For long-term storage (>6 months): Freeze at -20℃, protect from light, and store in a dry place for better stability.

The product vials should be kept sealed to prevent moisture absorption.

Prepared stock solution (DMSO solution) :

Store at -20°C away from light ; it will remain stable for several months. It can be stored for extended periods at -80°C .

It is recommended to label the preparation date and concentration.

Working solution (diluted in culture medium/buffer) :

It is recommended to prepare the solution immediately before use . If it needs to be prepared in advance, it should be refrigerated at 2-8℃ and used within 24 hours to prevent degradation or contamination.

Transportation conditions :

It can be transported at room temperature or with ice packs. For long-distance transport, it is recommended to use ice packs to maintain the low temperature.

Quality Advantages of Chinese Manufacturers

This product is manufactured by a high-quality chemical raw material manufacturer in China, strictly adhering to the ISO quality management system. The product quality is stable and reliable, making it an ideal choice for your research on NAD+ metabolism and aging.

✅Strict quality control :

High purity guaranteed : High performance liquid chromatography (HPLC) is used for purity analysis, with the main peak purity ≥98.5% , ensuring the accuracy and reproducibility of research data.

Structural verification : The product structure is precisely identified by proton/carbon nuclear magnetic resonance (¹H/¹³C NMR) and high-resolution mass spectrometry (HRMS) to ensure that the chemical structure is correct.

Strict impurity control : Organic impurities, inorganic salt residues, heavy metals (such as Pb, As, Hg, Cd) and solvent residues (such as DMSO, methanol, ethyl acetate, etc.) that may be generated during the synthesis process are strictly controlled to meet research-grade standards.

Stable physicochemical properties : Key physicochemical indicators such as appearance, melting point, moisture content, and solubility of the product are tested to ensure consistency between batches.

✅Professional production and packaging :

Production and packaging are carried out in cleanrooms that meet GMP standards to minimize the risk of cross-contamination and the introduction of foreign impurities.

Sterile, pyrogen-free, certified vials and butyl rubber stoppers are used for oxygen-free or nitrogen-filled packaging, which effectively prevents oxidation and deliquescence and ensures long-term product stability.

Provide detailed Certificates of Assessment (COA) and Material Safety Data Sheets (MSDS) to ensure transparent and traceable product information.

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